Kužela seminar series
Wed 25 Nov. 2009, 14:00
Title: Genome wide analysis of environmental stress response in yeast and close relatives
Speaker: Christoph Schüller, Department of Biochemistry and Cell Biology University of Vienna, Max F. Perutz Laboratories
Dr. Schüller started his independent research group, whose aim is to understand mechanisms involved in stress-induced changes in gene regulation in yeast, especially in the opportunistic pathogen Candida glabrata. He chose this human fungal pathogen fungus because of its similarity to S. cerevisiae. He suspected that the virulence of this fungus might be partly explained by adapted transcriptional patterns. He and and his colleagues characterized the environmental stress gene transcription program of C.glabrata. Also, in functional-genomic screens they uncovered a coordination of oxidative and nutrient stress responses. Furthermore, they are investigating host-pathogen interactions of the fungus with phagocytic cells. They found that a utophagocytic mechanisms greatly improve survival of C. glabrata in a phagocytosis situation. This exciting finding provides insights into the strategies of the fungal pathogen and opens an avenue to be followed in the future to integrate regulated autophagy and environmental stress response.