Bioinformatický seminár

Tue 5 Oct. 2010, 17:20

Title: Boyko et al. Complex population structure in African village dogs and its implications for inferring dog domestication history
Speaker: Peter Kováč, Laci Rampášek

High genetic diversity of East Asian village dogs has recently been used
to argue for an East Asian origin of the domestic dog. However, global
village dog genetic diversity and the extent to which semiferal village
dogs represent distinct, indigenous populations instead of admixtures of
various dog breeds has not been quantified. Understanding these issues is
critical to properly reconstructing the timing, number, and locations of
dog domestication. To address these questions, we sampled 318 village dogs
from 7 regions in Egypt, Uganda, and Namibia, measuring genetic diversity
>680 bp of the mitochondrial D-loop, 300 SNPs, and 89 microsatellite
markers. We also analyzed breed dogs, including putatively African breeds
(Afghan hounds, Basenjis, Pharaoh hounds, Rhodesian ridgebacks, and
Salukis), Puerto Rican street dogs, and mixed breed dogs from the United
States. Village dogs from most African regions appear genetically distinct
from non-native breed and mixed-breed dogs, although some individuals
cluster genetically with Puerto Rican dogs or United States breed mixes
instead of with neighboring village dogs. Thus, African village dogs are a
mosaic of indigenous dogs descended from early migrants to Africa, and
non-native, breed-admixed individuals. Among putatively African breeds,
Pharaoh hounds, and Rhodesian ridgebacks clustered with non-native rather
than indigenous African dogs, suggesting they have predominantly
non-African origins. Surprisingly, we find similar mtDNA haplotype
diversity in African and East Asian village dogs, potentially calling into
question the hypothesis of an East Asian origin for dog domestication.