Bioinformatický seminár

Tue 9 Nov. 2010, 17:20
I-9

Title: Chubb et al. Sequencing delivers diminishing returns for homology detection: implications for mapping the protein universe. Bioinformatics, 2010
Speaker: Martin Macko

MOTIVATION: Databases of sequenced genomes are widely used to characterize
the structure, function and evolutionary relationships of proteins. The
ability to discern such relationships is widely expected to grow as
sequencing projects provide novel information, bridging gaps in our map of
the protein universe. RESULTS: We have plotted our progress in protein
sequencing over the last two decades and found that the rate of novel
sequence discovery is in a sustained period of decline. Consequently,
PSI-BLAST, the most widely used method to detect remote evolutionary
relationships, which relies upon the accumulation of novel sequence data,
is now showing a plateau in performance. We interpret this trend as
signalling our approach to a representative map of the protein universe
and discuss its implications. CONTACT: daniel.chubb01@imperial.ac.uk
SUPPLEMENTARY INFORMATION: Supplementary data are available at
Bioinformatics online.