Mathematical Biology Seminar

Tue 21 Jun. 2011, 13:00

Title: Elongation process in transcription and translation
Speaker: Tomas Gedeon, University of Montana

Transcription of DNA and translation of mRNA are both processes
where a molecular machine moves along a one dimensional chain. In
a high growth conditions and for highly transcribed genes the
polymerases can experience traffic jams, which may lead to
significantly longer transcription times. Our goal is to quantify
this phenomena.

In this talk we will first review continuous time Markov models
and ordinary differential equations models for the elongation
process. Then we rigorously derive nonlinear scalar traffic model
as a limit of the ODE model. We then numerically illustrate the
effect of polymerase pausing on the transcriptional delay.

[ Webpage of the seminar ]