Bioinformatický seminár

Tue 20 Nov. 2012, 17:20

Title: Ilan Gronau et al. (2011) Bayesian inference of ancient human demography from individual genome sequences
Speaker: Lucia Simanová

Whole-genome sequences provide a rich source of information about human
evolution. Here we describe an effort to estimate key evolutionary parameters
based on the whole-genome sequences of six individuals from diverse human
populations. We used a Bayesian, coalescent-based approach to obtain information 
about ancestral population sizes, divergence times and migration rates from
inferred genealogies at many neutrally evolving loci across the genome. We
introduce new methods for accommodating gene flow between populations and
integrating over possible phasings of diploid genotypes. We also describe a
custom pipeline for genotype inference to mitigate biases from heterogeneous
sequencing technologies and coverage levels. Our analysis indicates that the San 
population of southern Africa diverged from other human populations approximately
108-157 thousand years ago, that Eurasians diverged from an ancestral African
population 38-64 thousand years ago, and that the effective population size of
the ancestors of all modern humans was approximately 9,000.