2-AIN-505, 2-AIN-251: Seminár z bioinformatiky (1) a (3)
Zima 2019

Mark R. Christie, Melanie L. Marine, Samuel E. Fox, Rod A. French, Michael S. Blouin. A single generation of domestication heritably alters the expression of hundreds of genes. Nat Commun, 7:10676. 2016.

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The genetic underpinnings associated with the earliest stages of plant and animal
domestication have remained elusive. Because a genome-wide response to selection 
can take many generations, the earliest detectable changes associated with
domestication may first manifest as heritable changes to global patterns of gene 
expression. Here, to test this hypothesis, we measured differential gene
expression in the offspring of wild and first-generation hatchery steelhead trout
(Oncorhynchus mykiss) reared in a common environment. Remarkably, we find that
there were 723 genes differentially expressed between the two groups of
offspring. Reciprocal crosses reveal that the differentially expressed genes
could not be explained by maternal effects or by chance differences in the
background levels of gene expression among unrelated families. Gene-enrichment
analyses reveal that adaptation to the novel hatchery environment involved
responses in wound healing, immunity and metabolism. These findings suggest that 
the earliest stages of domestication may involve adaptation to highly crowded