2-AIN-506, 2-AIN-252: Seminar in Bioinformatics (2), (4)
Summer 2025
Abstrakt

Gaetan Benoit, Sebastien Raguideau, Robert James, Adam M. Phillippy, Rayan Chikhi, Christopher Quince. High-quality metagenome assembly from long accurate reads with metaMDBG. Nature biotechnology, 42(9):1378-1383. 2024.

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Download from publisher: https://doi.org/10.1038/s41587-023-01983-6 PubMed

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Abstract:

We introduce metaMDBG, a metagenomics assembler for PacBio HiFi reads. MetaMDBG 
combines a de Bruijn graph assembly in a minimizer space with an iterative 
assembly over sequences of minimizers to address variations in genome coverage 
depth and an abundance-based filtering strategy to simplify strain complexity. 
For complex communities, we obtained up to twice as many high-quality 
circularized prokaryotic metagenome-assembled genomes as existing methods and had 
better recovery of viruses and plasmids.