Publication details

Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium, F. Liu, Y. Zhou, Z.Q. Wang, G. Lu, H. Zheng, P.J. Brindley, D.P. McManus, D. Blair, Q.H. Zhang, Y. Zhong, S. Wang, Z.G. Han, Z. Chen. The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature, 460(7253):345-351. 2009.
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Schistosoma japonicum is a parasitic flatworm that causes human
schistosomiasis, which is a significant cause of morbidity in China and
the Philippines. Here we present a draft genomic sequence for the worm.
The genome provides a global insight into the molecular architecture and
host interaction of this complex metazoan pathogen, revealing that it can
exploit host nutrients, neuroendocrine hormones and signalling pathways
for growth, development and maturation. Having a complex nervous system
and a well-developed sensory system, S. japonicum can accept stimulation
of the corresponding ligands as a physiological response to different
environments, such as fresh water or the tissues of its intermediate and
mammalian hosts. Numerous proteases, including cercarial elastase, are
implicated in mammalian skin penetration and haemoglobin degradation. The
genomic information will serve as a valuable platform to facilitate
development of new interventions for schistosomiasis control.



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