CB-aln-dp
Z MBI
Proteínové sekvencie a zarovnania
>sp|P50520|VPS34_SCHPO Phosphatidylinositol 3-kinase vps34 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=vps34 PE=2 SV=2 MDRLVFSYCPSSKVTARFLVKFCFIEYQDSQEPCICTIQLFSGNESGSLMQKCFVSKIPN KSLLPTELSKISTHEWLDFGVTVSELSLNAKFVVSAWKPSFNDEEVYEFVGCTTYRLFDE NNLLRQGLQKIPLQTSKEIKKYSPTSLELEQVKEINRLDGLLLKLQLGDVPSVNWLDDIS FGKIKDFRSKHMSLVTIPILYLDFLQFSFPVVFQRSYYPKSENRVYYSSFDLELNLDSPA ELKHRRLVRSQRNGPLDKDLKPNSKIRKELESILSYPPSEELSLEEKDLIWKFRFYLTRN KKAMTKFLKSVVWTDSSEVNQALSLLDSWTEIDIDDALELLSPSFVHPKVRAYAVSRLET ASNEELLLYLLQLVQALRYDNPISSDERFQPSPLALFLVNRAISSPSIGNDLYWYLVVEI EDEPVSKLFSSVMFLFQKELSKSVEGRLIRETLSAQAKFVEKLLRISKSVQSFRGTRLKK IEYLKVLLEDHKYHLLDFHALPLPLDPSVNIVGIIPDACTVFKSTMQPLRLLFKCQDGSK YPIIFKNGDDLRQDQLVIQILTLMDKLLKKEKLDLHLKPYRILATGPTHGAVQFVPSKTL ATILAEYHGSVLAYLRENNPDDGLNSANYGIDPVAMDNYVRSCAGYCVITYLLGVGDRHL DNLLITKDGHFFHADFGYILGRDPKLFSPAMKLSKEMVEGMGGYNSPFYQQFKSYCYTTF TALRKSSNLILNLFSLMVDANIPDIKFDKEKVVYKVKERFCLQMSESDAIKYFEQLINDS VSALFPQIIDRMHNLAQYMRS
>tr|B1AKP8|B1AKP8_HUMAN FK506 binding protein 12-rapamycin associated protein 1 OS=Homo sapiens GN=FRAP1 PE=4 SV=1 MNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAES TENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGH WPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYP LTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEAS RLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVK DLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQS IAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTS LRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDY DHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILG LGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGN YRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSV EILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSH DDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW
########################################
# Program: water
# Rundate: Thu 11 Oct 2012 09:37:58
# Commandline: water
# -asequence ggg1
# -bsequence ggg2
# -outfile ggg12.w
# Align_format: srspair
# Report_file: ggg12.w
########################################
#=======================================
#
# Aligned_sequences: 2
# 1: VPS34_SCHPO
# 2: B1AKP8_HUMAN
# Matrix: EBLOSUM62
# Gap_penalty: 10.0
# Extend_penalty: 0.5
#
# Length: 645
# Identity: 124/645 (19.2%)
# Similarity: 221/645 (34.3%)
# Gaps: 211/645 (32.7%)
# Score: 226.0
#
#
#=======================================
VPS34_SCHPO 235 NLDSPAELKHRRLVRSQRNGPLDKDLKPNSKIRKELESILSYPPSEELSL 284
|.:|.|| |..|.|....|: .|:.::|...|
B1AKP8_HUMAN 53 NSESEAE--------STENSPTPSPLQ--KKVTEDLSKTL---------- 82
VPS34_SCHPO 285 EEKDLIWKFRFYLTRNKKAMTKFLKSVVWTDSSEVNQALSLLDSWTEI-- 332
|.....|:..|.:|:..:..:.:...|.:|..|.:.
B1AKP8_HUMAN 83 ------------LMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGH 120
VPS34_SCHPO 333 --DIDDALELLSPSFVHPKVRAYAVSRLETASNEELLLYLLQLVQAL--R 378
|:::|| |......:::| .||::..| |
B1AKP8_HUMAN 121 WPDVNEAL-----------VEGVKAIQIDT---------WLQVIPQLIAR 150
VPS34_SCHPO 379 YDNP-----------ISSDERFQPS----PLAL----------------- 396
.|.| ::...|:.|. ||.:
B1AKP8_HUMAN 151 IDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKIL 200
VPS34_SCHPO 397 --------FLVNRA--ISSPSIGNDLYWYLVVEIEDEPVSKLF---SSVM 433
.||.:| :|...|...:.|:.:.....|..|:|: .:|.
B1AKP8_HUMAN 201 KNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVK 250
VPS34_SCHPO 434 FLFQ----------------KELS-----------------KSVEGRLIR 450
.:|: ||.| |.::...::
B1AKP8_HUMAN 251 GMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVK 300
VPS34_SCHPO 451 ETLSAQAKFVEKLLRISKSVQSFRGTRLKKIEYLKVLLEDHKYHLLDFHA 500
:...|...:.....||||.:.......|:.:....::..|.:. |
B1AKP8_HUMAN 301 DLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLEL------A 344
VPS34_SCHPO 501 LPLPLDPSVNIVGI--IPDACTVFKSTMQPLRLLFKCQDGSKYPIIFKNG 548
:|...||:..|:.| |..:..|..|..:|.:|.....:|.::..:.|..
B1AKP8_HUMAN 345 VPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGH 394
VPS34_SCHPO 549 DDLRQDQLVIQILTLMDKLLKKE----KLDLHLKPYRILATGPTHGAVQF 594
:|||||:.|:|:..|::.||..: :.:|.::.|.::......|.:.:
B1AKP8_HUMAN 395 EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGW 444
VPS34_SCHPO 595 VP-SKTLATILAEYHG-----------------------------SVLAY 614
|| ..||..::.:|.. .|..:
B1AKP8_HUMAN 445 VPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEH 494
VPS34_SCHPO 615 LRENNPDDGLNSANYGIDP---VAMD---NYVRSCAGYCVITYLLGVGDR 658
...|...|.|....:...| |..| ||.||.|...::.|:||:|||
B1AKP8_HUMAN 495 AVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDR 544
VPS34_SCHPO 659 HLDNLLITK-DGHFFHADFG--------------YILGRDPKLFSPAMKL 693
|..||::.: .|...|.||| .|..|..::.:.||:
B1AKP8_HUMAN 545 HPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAME- 593
VPS34_SCHPO 694 SKEMVEGMGGYNSPFYQQFKSYCYTTFTALRKSSNLILNLFSLMV 738
|.|:.| .::..|:|....||:..:.::.:....|
B1AKP8_HUMAN 594 ----VTGLDG-------NYRITCHTVMEVLREHKDSVMAVLEAFV 627
########################################
# Program: needle
# Rundate: Thu 11 Oct 2012 09:40:40
# Commandline: needle
# -asequence ggg1
# -bsequence ggg2
# -endweight
# -outfile ggg12.n2
# Align_format: srspair
# Report_file: ggg12.n2
########################################
#=======================================
#
# Aligned_sequences: 2
# 1: VPS34_SCHPO
# 2: B1AKP8_HUMAN
# Matrix: EBLOSUM62
# Gap_penalty: 10.0
# Extend_penalty: 0.5
#
# Length: 948
# Identity: 167/948 (17.6%)
# Similarity: 292/948 (30.8%)
# Gaps: 341/948 (36.0%)
# Score: 130.5
#
#
#=======================================
VPS34_SCHPO 1 MD-RLVFSYCPSSKVTARFLVKFCFIEYQDSQEPCICTIQLFSGNESGSL 49
|: ..|..| ::|: ...:....
B1AKP8_HUMAN 1 MNFEAVLHY-----------------KHQN------------QARDEKKK 21
VPS34_SCHPO 50 MQKCFVSKIPNKSLLPTELSKISTHEWLDFGVTVSELSLNAKFVVSAWKP 99
::....:.|.|.:...|..:..:| :|...
B1AKP8_HUMAN 22 LRHASGANITNATTAATTAATATT---------------------TASTE 50
VPS34_SCHPO 100 SFNDEEVYEFVGCTTYRLFDENNLLRQGLQ-KIPLQTSKEIKKYSPTSLE 148
..|.|...|.. ||:.....|| |:....||.:..|:..:::
B1AKP8_HUMAN 51 GSNSESEAEST---------ENSPTPSPLQKKVTEDLSKTLLMYTVPAVQ 91
VPS34_SCHPO 149 ----LEQVKEINRLDGLLLKLQLGDVPSVNWLDDISFGKIKDFRSKHMSL 194
...:...|.|...|..|.| |.| :|...|... :|
B1AKP8_HUMAN 92 GFFRSISLSRGNNLQDTLRVLTL-------WFD---YGHWPDVNE---AL 128
VPS34_SCHPO 195 VT-IPILYLDFLQFSFPVVFQRSYYPKSENRVYYSSFDLELNLDSP---- 239
|. :..:.:|......|.:..| :|:|
B1AKP8_HUMAN 129 VEGVKAIQIDTWLQVIPQLIAR--------------------IDTPRPLV 158
VPS34_SCHPO 240 AELKHRRLVRSQRNGPLDKDLKPNSKIRKELESILSYPPSEELSLEEKDL 289
..|.|:.|....|..| ..|.|| |::..|..
B1AKP8_HUMAN 159 GRLIHQLLTDIGRYHP----------------QALIYP----LTVASKST 188
VPS34_SCHPO 290 IWKFRFYLTRNKKAMTKFLKSVVWTDSSEVNQALSLLDSWTEIDI----- 334
.|....|..|.||::....::.|.||:.:.:....:.|
B1AKP8_HUMAN 189 -------TTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEM 231
VPS34_SCHPO 335 -DDALELLSPSFVHPKVRAYAVSRLETASNEELLLYLLQLVQALRYDNPI 383
.:.||..| |.|...| |.:.:..:|:.:.|:.
B1AKP8_HUMAN 232 WHEGLEEAS--------RLYFGER-----NVKGMFEVLEPLHAMM----- 263
VPS34_SCHPO 384 SSDERFQPSPLALFLVNRAISSPSIGNDLYWYLVVEIEDEPVSKLFSSVM 433
|| .|..|.....|:| .|.|| :|.
B1AKP8_HUMAN 264 ---ER-GPQTLKETSFNQA-----YGRDL-----MEA------------- 286
VPS34_SCHPO 434 FLFQKELSKSVEGRLIRETLSAQAKFVEKLLRISKSVQSFRGTRLKKIEY 483
|:...|.::...:::...|...:.....||||.:.......|:.:..
B1AKP8_HUMAN 287 ---QEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSP 333
VPS34_SCHPO 484 LKVLLEDHKYHLLDFHALPLPLDPSVNIVGI--IPDACTVFKSTMQPLRL 531
..::..|.:. |:|...||:..|:.| |..:..|..|..:|.:|
B1AKP8_HUMAN 334 KLLMCRDLEL------AVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKL 377
VPS34_SCHPO 532 LFKCQDGSKYPIIFKNGDDLRQDQLVIQILTLMDKLLKKE----KLDLHL 577
.....:|.::..:.|..:|||||:.|:|:..|::.||..: :.:|.:
B1AKP8_HUMAN 378 TLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSI 427
VPS34_SCHPO 578 KPYRILATGPTHGAVQFVP-SKTLATILAEYHG----------------- 609
:.|.::......|.:.:|| ..||..::.:|..
B1AKP8_HUMAN 428 QRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMA 477
VPS34_SCHPO 610 ------------SVLAYLRENNPDDGLNSANYGIDP---VAMD---NYVR 641
.|..:...|...|.|....:...| |..| ||.|
B1AKP8_HUMAN 478 PDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTR 527
VPS34_SCHPO 642 SCAGYCVITYLLGVGDRHLDNLLITK-DGHFFHADFG------------- 677
|.|...::.|:||:||||..||::.: .|...|.|||
B1AKP8_HUMAN 528 SLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFP 577
VPS34_SCHPO 678 -YILGRDPKLFSPAMKLSKEMVEGMGGYNSPFYQQFKSYCYTTFTALRKS 726
.|..|..::.:.||: |.|:.| .::..|:|....||:.
B1AKP8_HUMAN 578 EKIPFRLTRMLTNAME-----VTGLDG-------NYRITCHTVMEVLREH 615
VPS34_SCHPO 727 SNLILNLFSLMV----------DAN------------------------- 741
.:.::.:....| |.|
B1AKP8_HUMAN 616 KDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG 665
VPS34_SCHPO 742 --------------IPD----------IK---FDKE--KVVYKVKERFC- 761
:|: :| .:|: :::.:|:::..
B1AKP8_HUMAN 666 VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTG 715
VPS34_SCHPO 762 LQMSESDAI---KYFEQLINDSVSALFPQIIDRMHNLAQYMRS----- 801
...|..|.: ...|.||..:.| ..||.|....
B1AKP8_HUMAN 716 RDFSHDDTLDVPTQVELLIKQATS---------HENLCQCYIGWCPFW 754
########################################
# Program: needle
# Rundate: Thu 11 Oct 2012 09:37:33
# Commandline: needle
# -asequence ggg1
# -bsequence ggg2
# -outfile ggg12.n
# Align_format: srspair
# Report_file: ggg12.n
########################################
#=======================================
#
# Aligned_sequences: 2
# 1: VPS34_SCHPO
# 2: B1AKP8_HUMAN
# Matrix: EBLOSUM62
# Gap_penalty: 10.0
# Extend_penalty: 0.5
#
# Length: 1060
# Identity: 138/1060 (13.0%)
# Similarity: 245/1060 (23.1%)
# Gaps: 565/1060 (53.3%)
# Score: 206.0
#
#
#=======================================
VPS34_SCHPO 1 MDRLVFSYCPSSKVTARFLVKFCFIEYQDSQEPCICTIQLFSGNESGSLM 50
B1AKP8_HUMAN 0 -------------------------------------------------- 0
VPS34_SCHPO 51 QKCFVSKIPNKSLLPTELSKISTHEWLDFGVTVSELSLNAKFVVSAWKPS 100
B1AKP8_HUMAN 0 -------------------------------------------------- 0
VPS34_SCHPO 101 FNDEEVYEFVGCTTYRLFDENNLLRQGLQKIPLQTSKEIKKYSPTSLELE 150
B1AKP8_HUMAN 0 -------------------------------------------------- 0
VPS34_SCHPO 151 QVKEINRLDGLLLKLQLGDVPSVNWLDDISFGKIKDFRSKHMSLVTIPIL 200
B1AKP8_HUMAN 0 -------------------------------------------------- 0
VPS34_SCHPO 201 YLDFLQFSFPVVFQRSYYPKSENRVYYSSFDLELNLDSPAELKHRRLVRS 250
:|.::....||:...|.
B1AKP8_HUMAN 1 ---------------------------------MNFEAVLHYKHQNQARD 17
VPS34_SCHPO 251 QRNGPLDKDLK--------------------------PNSKIRKELESIL 274
:: |.|: ..|....|.||..
B1AKP8_HUMAN 18 EK-----KKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTE 62
VPS34_SCHPO 275 SYP-PSEELSLEEKDLIWKFRFYLTRNKKAMTKFLKSVVWTDSSEVNQAL 323
:.| ||.......:||......|.. .|:..|.:|:..:..:.:...|
B1AKP8_HUMAN 63 NSPTPSPLQKKVTEDLSKTLLMYTV---PAVQGFFRSISLSRGNNLQDTL 109
VPS34_SCHPO 324 SLLDSWTEI----DIDDALELLSPSFVHPKVRAYAVSRLETASNEELLLY 369
.:|..|.:. |:::|| |......:::|
B1AKP8_HUMAN 110 RVLTLWFDYGHWPDVNEAL-----------VEGVKAIQIDT--------- 139
VPS34_SCHPO 370 LLQLVQAL--RYDNP-----------ISSDERFQPS----PLAL------ 396
.||::..| |.|.| ::...|:.|. ||.:
B1AKP8_HUMAN 140 WLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTT 189
VPS34_SCHPO 397 -------------------FLVNRA--ISSPSIGNDLYWYLVVEIEDEPV 425
.||.:| :|...|...:.|:.:.....|..
B1AKP8_HUMAN 190 TARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEA 239
VPS34_SCHPO 426 SKLF---SSVMFLFQ----------------KELS--------------- 441
|:|: .:|..:|: ||.|
B1AKP8_HUMAN 240 SRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEW 289
VPS34_SCHPO 442 --KSVEGRLIRETLSAQAKFVEKLLRISKSVQSFRGTRLKKIEYLKVLLE 489
|.::...:::...|...:.....||||.:.......|:.:....::..
B1AKP8_HUMAN 290 CRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCR 339
VPS34_SCHPO 490 DHKYHLLDFHALPLPLDPSVNIVGI--IPDACTVFKSTMQPLRLLFKCQD 537
|.:. |:|...||:..|:.| |..:..|..|..:|.:|.....:
B1AKP8_HUMAN 340 DLEL------AVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSN 383
VPS34_SCHPO 538 GSKYPIIFKNGDDLRQDQLVIQILTLMDKLLKKE----KLDLHLKPYRIL 583
|.::..:.|..:|||||:.|:|:..|::.||..: :.:|.::.|.::
B1AKP8_HUMAN 384 GHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVI 433
VPS34_SCHPO 584 ATGPTHGAVQFVP-SKTLATILAEYHG----------------------- 609
......|.:.:|| ..||..::.:|..
B1AKP8_HUMAN 434 PLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHL 483
VPS34_SCHPO 610 ------SVLAYLRENNPDDGLNSANYGIDP---VAMD---NYVRSCAGYC 647
.|..:...|...|.|....:...| |..| ||.||.|...
B1AKP8_HUMAN 484 TLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMS 533
VPS34_SCHPO 648 VITYLLGVGDRHLDNLLITK-DGHFFHADFG--------------YILGR 682
::.|:||:||||..||::.: .|...|.||| .|..|
B1AKP8_HUMAN 534 MVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFR 583
VPS34_SCHPO 683 DPKLFSPAMKLSKEMVEGMGGYNSPFYQQFKSYCYTTFTALRKSSNLILN 732
..::.:.||: |.|:.| .::..|:|....||:..:.::.
B1AKP8_HUMAN 584 LTRMLTNAME-----VTGLDG-------NYRITCHTVMEVLREHKDSVMA 621
VPS34_SCHPO 733 LFSLMV----------DANIPDIKFDKEKVVYKVKERFCLQMSESDAIKY 772
:....| |.|....|..:.:
B1AKP8_HUMAN 622 VLEAFVYDPLLNWRLMDTNTKGNKRSRTR--------------------- 650
VPS34_SCHPO 773 FEQLINDSVSA-LFPQIIDRMHNLAQYMRS-------------------- 801
.||.|| ...:|:|.: .|.:....
B1AKP8_HUMAN 651 -----TDSYSAGQSVEILDGV-ELGEPAHKKTGTTVPESIHSFIGDGLVK 694
VPS34_SCHPO 801 -------------------------------------------------- 801
B1AKP8_HUMAN 695 PEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLC 744
VPS34_SCHPO 801 ---------- 801
B1AKP8_HUMAN 745 QCYIGWCPFW 754
