2-AIN-506 a 2-AIN-252: Seminár z bioinformatiky (2) a (4)
Leto 2016

Bo Wang, Aziz M. Mezlini, Feyyaz Demir, Marc Fiume, Zhuowen Tu, Michael Brudno, Benjamin Haibe-Kains, Anna Goldenberg. Similarity network fusion for aggregating data types on a genomic scale. Nature methods, 11(3):333-337. 2014.

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Recent technologies have made it cost-effective to collect diverse types of
genome-wide data. Computational methods are needed to combine these data to
create a comprehensive view of a given disease or a biological process.
Similarity network fusion (SNF) solves this problem by constructing networks of
samples (e.g., patients) for each available data type and then efficiently fusing
these into one network that represents the full spectrum of underlying data. For 
example, to create a comprehensive view of a disease given a cohort of patients, 
SNF computes and fuses patient similarity networks obtained from each of their
data types separately, taking advantage of the complementarity in the data. We
used SNF to combine mRNA expression, DNA methylation and microRNA (miRNA)
expression data for five cancer data sets. SNF substantially outperforms single
data type analysis and established integrative approaches when identifying cancer
subtypes and is effective for predicting survival.