2-AIN-506 a 2-AIN-252: Seminár z bioinformatiky (2) a (4)
Leto 2019
Abstrakt

Jeffrey Rogers, Muthuswamy Raveendran, R. Alan Harris, Thomas Mailund, Kalle Leppala, Georgios Athanasiadis, Mikkel Heide Schierup, Jade Cheng, Kasper Munch, Jerilyn A. Walker, Miriam K. Konkel, Vallmer Jordan, Cody J. Steely, Thomas O. Beckstrom, Christina Bergey, Andrew Burrell, Dominik Schrempf, Angela Noll, Maximillian Kothe, Gisela H. Kopp, Yue Liu, Shwetha Murali, Konstantinos Billis, Fergal J. Martin, Matthieu Muffato, Laura Cox, James Else, Todd Disotell, Donna M. Muzny, Jane Phillips-Conroy, Bronwen Aken, Evan E. Eichler, Tomas Marques-Bonet, Carolin Kosiol, Mark A. Batzer, Matthew W. Hahn, Jenny Tung, Dietmar Zinner, Christian Roos, Clifford J. Jolly, Richard A. Gibbs, Kim C. Worley. The comparative genomics and complex population history of Papio baboons. Sci Adv, 5(1):eaau6947. 2019.

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Abstract:

Recent studies suggest that closely related species can accumulate substantial
genetic and phenotypic differences despite ongoing gene flow, thus challenging
traditional ideas regarding the genetics of speciation. Baboons (genus Papio) are
Old World monkeys consisting of six readily distinguishable species. Baboon
species hybridize in the wild, and prior data imply a complex history of
differentiation and introgression. We produced a reference genome assembly for
the olive baboon (Papio anubis) and whole-genome sequence data for all six extant
species. We document multiple episodes of admixture and introgression during the 
radiation of Papio baboons, thus demonstrating their value as a model of complex 
evolutionary divergence, hybridization, and reticulation. These results help
inform our understanding of similar cases, including modern humans, Neanderthals,
Denisovans, and other ancient hominins.