Yu Zhang, Giltae Song, Tomas Vinar, Eric D. Green, Adam Siepel, Webb Miller. Reconstructing the Evolutionary History of Complex Human Gene Clusters. In Research in Computational Molecular Biology: 12th Annual International Conference (RECOMB), 4955 volume of Lecture Notes in Bioinformatics, pp. 29-49, 2008. Springer.

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Abstract:

Clusters of genes that evolved from single progenitors via repeated
segmental duplications present significant challenges to the
generation of a truly complete human genome sequence. Such clusters
can confound both accurate sequence assembly and downstream
computational analyses, yet they represent a hotbed of functional
innovation, making them of extreme interest. We have developed an
algorithm for reconstructing the evolutionary history of gene clusters
using only human genomic sequence data. This method allows the tempo
of large-scale evolutionary events in human gene clusters to be
estimated, which in turn will facilitate primate comparative
sequencing studies that will aim to reconstruct their evolutionary
history more fully.

Last update: 09/15/2008