2-AIN-506 a 2-AIN-252: Seminár z bioinformatiky (2) a (4)
Leto 2015
Abstrakt

Najeeb Halabi, Olivier Rivoire, Stanislas Leibler, Rama Ranganathan. Protein sectors: evolutionary units of three-dimensional structure. Cell, 138(4):774-776. 2009.

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Abstract:

Proteins display a hierarchy of structural features at primary, secondary,
tertiary, and higher-order levels, an organization that guides our current
understanding of their biological properties and evolutionary origins. Here, we
reveal a structural organization distinct from this traditional hierarchy by
statistical analysis of correlated evolution between amino acids. Applied to the 
S1A serine proteases, the analysis indicates a decomposition of the protein into 
three quasi-independent groups of correlated amino acids that we term \"protein
sectors.\" Each sector is physically connected in the tertiary structure, has a
distinct functional role, and constitutes an independent mode of sequence
divergence in the protein family. Functionally relevant sectors are evident in
other protein families as well, suggesting that they may be general features of
proteins. We propose that sectors represent a structural organization of proteins
that reflects their evolutionary histories.