2-AIN-506, 2-AIN-252: Seminar in Bioinformatics (2), (4)
Summer 2025
Abstrakt

Endre Neparaczki, Luca Kis, Zoltan Maroti, Bence Kovacs, Gergely I. B. Varga, Miklos Makoldi, Pamjav Horolma, Eva Teiszler, Balazs Tihanyi, Peter L. Nagy, Kitti Maar, Attila Gyenesei, Oszkar Schutz, Eszter Dudas, Tibor Torok, Vesna Pascuttini-Juraga, Ivancica Peharda, Laszlo Tamas Vizi, Gabor Horvath-Lugossy, Miklos Kasler. The genetic legacy of the Hunyadi descendants. Heliyon, 8(11):e11731. 2022.

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Abstract:

The Hunyadi family is one of the most influential families in the history of 
Central Europe in the 14th-16th centuries. The family's prestige was established 
by Johannes Hunyadi, a Turk-beater who rose to the position of governor of the 
Kingdom of Hungary. His second son, Matthias Hunyadi, became the elected ruler of 
the Kingdom of Hungary in 1458. The Hunyadi family had unknown origin. Moreover, 
Matthias failed to found a dynasty because of lacking a legitimate heir and his 
illegitimate son Johannes Corvinus was unable to obtain the crown. His grandson, 
Christophorus Corvinus, died in childhood, thus the direct male line of the 
family ended. In the framework of on interdisciplinary research, we have 
determined the whole genome sequences of Johannes Corvinus and Christophorus 
Corvinus by next-generation sequencing technology. Both of them carried the 
Y-chromosome haplogroup is E1b1b1a1b1a6a1c  approximately , which is widespread in Eurasia. The 
father-son relationship was verified using the classical STR method and whole 
genome data. Christophorus Corvinus belongs to the rare, sporadically occurring 
T2c1+146 mitochondrial haplogroup, most frequent around the Mediterranean, while 
his father belongs to the T2b mitochondrial haplogroup, widespread in Eurasia, 
both are consistent with the known origin of the mothers. Archaeogenomic analysis 
indicated that the Corvinus had an ancient European genome composition. Based on 
the reported genetic data, it will be possible to identify all the other Hunyadi 
family member, whose only known grave site is known, but who are resting assorted 
with several other skeletons.