2-AIN-505, 2-AIN-251: Seminar in Bioinformatics (1), (3)
Winter 2024
Abstrakt

Michel {van Kempen}, Stephanie S. Kim, Charlotte Tumescheit, Milot Mirdita, Jeongjae Lee, Cameron L. M. Gilchrist, Johannes Soding, Martin Steinegger. Fast and accurate protein structure search with Foldseek. Nature biotechnology, 42(2):243-246. 2024.

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Abstract:

https://www.youtube.com/watch?v=IJtWTxhuunk

As structure prediction methods are generating millions of publicly available 
protein structures, searching these databases is becoming a bottleneck. Foldseek 
aligns the structure of a query protein against a database by describing tertiary 
amino acid interactions within proteins as sequences over a structural alphabet. 
Foldseek decreases computation times by four to five orders of magnitude with 
86%, 88% and 133% of the sensitivities of Dali, TM-align and CE, respectively.