Basic Information

NameIntron-encoded DNA endonuclease aI4 (DNA endonuclease I-SceII) [Cleaved into: Truncated non-functional cytochrome oxidase 1; DNA endonuclease aI4 (EC 3.1.-.-) (Intron-encoded endonuclease I-SceII)]
Uniprot IDP03878
Systematic gene nameQ0065
Standard gene nameAI4
Gene namesAI4 ENS2 I-SCEII Q0065
Description from SGDQ0065 AI4 SGDID:S000007264, Chr Mito from 13818-13986,16435-16470,18954-18991,20508-21935, Genome Release 64-3-1, Verified ORF, "Endonuclease I-SceII; encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity"
Protein length556
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG
NSQLFNVLVV GHAVLMIFFL VMPALIGGFG NYLLPLMIGA TDTAFPRINN
IAFWVLPMGL VCLVTSTLVE SGAGTGWTVY PPLSSIQAHS GPSVDLAIFA
LHLTSISSLL GAINFIVTTL NMRTNGMTMH KLPLFVWSIF ITAFLLLLSL
PVLSAGITML LLDRNFNTSF FEVSGGGDPI LYEHLFWFFG QTVATIIMLM
MYNDMHFSKC WKLLKKWITN IMSTLFKALF VKMFMSYNNQ QDKMMNNTML
KKDNIKRSSE TTRKMLNNSM NKKFNQWLAG LIDGDGYFGI VSKKYVSLEI
TVALEDEMAL KEIQNKFGGS IKLRSGVKAI RYRLTNKTGM IKLINAVNGN
IRNTKRLVQF NKVCILLGID FIYPIKLTKD NSWFVGFFDA DGTINYSFKN
NHPQLTISVT NKYLQDVQEY KNILGGNIYF DKSQNGYYKW SIQSKDMVLN
FINDYIKMNP SRTTKMNKLY LSKEFYNLKE LKAYNKSSDS MQYKAWLNFE
NKWKNK

Legend

  • X K-Succinylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


Use imported representation

Loading structure from server... It may take a while.

If you believe something went wrong, please make sure PDB ID is correct.
Please also make sure that WebGL is enabled in your browser.

References

[529, K-succ]Weinert, B.T., Schölz, C., Wagner, S.A., et al. (2013). Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Reports, 4(4), 842-851. (Publication) (All modifications)
[529, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)