Basic Information
Name | DNA polymerase gamma (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) |
Uniprot ID | P15801 |
Systematic gene name | YOR330C |
Standard gene name | MIP1 |
Gene names | MIP1 YOR330C |
Description from SGD | YOR330C MIP1 SGDID:S000005857, Chr XV from 943385-939621, Genome Release 64-3-1, reverse complement, Verified ORF, "Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occur more frequently in some lab strains; human ortholog POLG complements yeast mip1 mutant; mutations in human POLG associated with Alpers-Huttenlocher syndrome (AHS), progressive external ophthalmoplegia (PEO), parkinsonism, other mitochondrial diseases" |
Protein length | 1254 |
Download | sequence (fasta, from Uniprot), modifications (csv format) |
Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MTKLMVRSEC MLRMVRRRPL RVQFCARWFS TKKNTAEAPR INPVGIQYLG
ESLQRQVFGS CGGKDEVEQS DKLMELSKKS LKDHGLWGKK TLITDPISFP
LPPLQGRSLD EHFQKIGRFN SEPYKSFCED KFTEMVARPA EWLRKPGWVK
YVPGMAPVEV AYPDEELVVF DVETLYNVSD YPTLATALSS TAWYLWCSPF
ICGGDDPAAL IPLNTLNKEQ VIIGHNVAYD RARVLEEYNF RDSKAFFLDT
QSLHIASFGL CSRQRPMFMK NNKKKEAEVE SEVHPEISIE DYDDPWLNVS
ALNSLKDVAK FHCKIDLDKT DRDFFASTDK STIIENFQKL VNYCATDVTA
TSQVFDEIFP VFLKKCPHPV SFAGLKSLSK CILPTKLNDW NDYLNSSESL
YQQSKVQIES KIVQIIKDIV LLKDKPDFYL KDPWLSQLDW TTKPLRLTKK
GVPAKCQKLP GFPEWYRQLF PSKDTVEPKI TIKSRIIPIL FKLSWENSPV
IWSKESGWCF NVPHEQVETY KAKNYVLADS VSQEEEEIRT HNLGLQCTGV
LFKVPHPNGP TFNCTNLLTK SYNHFFEKGV LKSESELAHQ ALQINSSGSY
WMSARERIQS QFVVPSCKFP NEFQSLSAKS SLNNEKTNDL AIIIPKIVPM
GTITRRAVEN AWLTASNAKA NRIGSELKTQ VKAPPGYCFV GADVDSEELW
IASLVGDSIF NVHGGTAIGW MCLEGTKNEG TDLHTKTAQI LGCSRNEAKI
FNYGRIYGAG AKFASQLLKR FNPSLTDEET KKIANKLYEN TKGKTKRSKL
FKKFWYGGSE SILFNKLESI AEQETPKTPV LGCGITYSLM KKNLRANSFL
PSRINWAIQS SGVDYLHLLC CSMEYIIKKY NLEARLCISI HDEIRFLVSE
KDKYRAAMAL QISNIWTRAM FCQQMGINEL PQNCAFFSQV DIDSVIRKEV
NMDCITPSNK TAIPHGEALD INQLLDKSNS KLGKPNLDID SKVSQYAYNY
REPVFEEYNK SYTPEFLKYF LAMQVQSDKR DVNRLEDEYL RECTSKEYAR
DGNTAEYSLL DYIKDVEKGK RTKVRIMGSN FLDGTKNAKA DQRIRLPVNM
PDYPTLHKIA NDSAIPEKQL LENRRKKENR IDDENKKKLT RKKNTTPMER
KYKRVYGGRK AFEAFYECAN KPLDYTLETE KQFFNIPIDG VIDDVLNDKS
NYKKKPSQAR TASSSPIRKT AKAVHSKKLP ARKSSTTNRN LVELERDITI
SREY
ESLQRQVFGS CGGKDEVEQS DKLMELSKKS LKDHGLWGKK TLITDPISFP
LPPLQGRSLD EHFQKIGRFN SEPYKSFCED KFTEMVARPA EWLRKPGWVK
YVPGMAPVEV AYPDEELVVF DVETLYNVSD YPTLATALSS TAWYLWCSPF
ICGGDDPAAL IPLNTLNKEQ VIIGHNVAYD RARVLEEYNF RDSKAFFLDT
QSLHIASFGL CSRQRPMFMK NNKKKEAEVE SEVHPEISIE DYDDPWLNVS
ALNSLKDVAK FHCKIDLDKT DRDFFASTDK STIIENFQKL VNYCATDVTA
TSQVFDEIFP VFLKKCPHPV SFAGLKSLSK CILPTKLNDW NDYLNSSESL
YQQSKVQIES KIVQIIKDIV LLKDKPDFYL KDPWLSQLDW TTKPLRLTKK
GVPAKCQKLP GFPEWYRQLF PSKDTVEPKI TIKSRIIPIL FKLSWENSPV
IWSKESGWCF NVPHEQVETY KAKNYVLADS VSQEEEEIRT HNLGLQCTGV
LFKVPHPNGP TFNCTNLLTK SYNHFFEKGV LKSESELAHQ ALQINSSGSY
WMSARERIQS QFVVPSCKFP NEFQSLSAKS SLNNEKTNDL AIIIPKIVPM
GTITRRAVEN AWLTASNAKA NRIGSELKTQ VKAPPGYCFV GADVDSEELW
IASLVGDSIF NVHGGTAIGW MCLEGTKNEG TDLHTKTAQI LGCSRNEAKI
FNYGRIYGAG AKFASQLLKR FNPSLTDEET KKIANKLYEN TKGKTKRSKL
FKKFWYGGSE SILFNKLESI AEQETPKTPV LGCGITYSLM KKNLRANSFL
PSRINWAIQS SGVDYLHLLC CSMEYIIKKY NLEARLCISI HDEIRFLVSE
KDKYRAAMAL QISNIWTRAM FCQQMGINEL PQNCAFFSQV DIDSVIRKEV
NMDCITPSNK TAIPHGEALD INQLLDKSNS KLGKPNLDID SKVSQYAYNY
REPVFEEYNK SYTPEFLKYF LAMQVQSDKR DVNRLEDEYL RECTSKEYAR
DGNTAEYSLL DYIKDVEKGK RTKVRIMGSN FLDGTKNAKA DQRIRLPVNM
PDYPTLHKIA NDSAIPEKQL LENRRKKENR IDDENKKKLT RKKNTTPMER
KYKRVYGGRK AFEAFYECAN KPLDYTLETE KQFFNIPIDG VIDDVLNDKS
NYKKKPSQAR TASSSPIRKT AKAVHSKKLP ARKSSTTNRN LVELERDITI
SREY
Legend
- X Phoshorylation
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
[791, Phos] | Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications) |
[791, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |
[795, Phos] | Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications) |
[795, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |