Basic Information

NameProtein ATP12, mitochondrial
Uniprot IDP22135
Systematic gene nameYJL180C
Standard gene nameATP12
Gene namesATP12 YJL180C J0486
Description from SGDYJL180C ATP12 SGDID:S000003716, Chr X from 88560-87583, Genome Release 64-3-1, reverse complement, Verified ORF, "Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency"
Protein length325
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MLPSLRKGCF IVNSIRLKLP RFYSLNAQPL GTDNTIENNT PTETNRLSKT
SQKFWEKVSL NRDVEKGKIA LQLDGRTIKT PLGNGIIVDN AKSLLAYLLK
LEWSSLSSLS IKTHSLPLTS LVARCIDLQM TNEPGCDPQL VAKIGGNSDV
IKNQLLRYLD TDTLLVFSPM NEFEGRLRNA QNELYIPIIK GMEEFLRNFS
SESNIRLQIL DADIHGLRGN QQSDIVKNAA KKYMSSLSPW DLAILEKTVL
TTKSFICGVL LLENKKDTAN LIPALKTDMD NIVRAATLET IFQVEKWGEV
EDTHDVDKRD IRRKIHTAAI AAFKQ

Legend

  • X Phoshorylation
  • X K-Succinylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[24, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[53, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)
[57, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)
[77, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)