Basic Information

NamePeptide chain release factor 1, mitochondrial (MRF-1) (MtRF-1)
Uniprot IDP30775
Systematic gene nameYGL143C
Standard gene nameMRF1
Gene namesMRF1 YGL143C
Description from SGDYGL143C MRF1 SGDID:S000003111, Chr VII from 235958-234717, Genome Release 64-3-1, reverse complement, Verified ORF, "Mitochondrial translation release factor; involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability"
Protein length413
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MWLSKFQFPS RSIFKGVFLG HKLPLLVRLT STTTNSKSNG SIPTQYTELS
PLLVKQAEKY EAELKDLDKD LSCGIHFDVN KQKHYAKLSA LTDTFIEYKE
KLNELKSLQE MIVSDPSLRA EAEQEYAELV PQYETTSSRL VNKLLPPHPF
ADKPSLLELR PGVGGIEAMI FTQNLLDMYI GYANYRKWKY RIISKNENES
GSGIIDAILS IEEAGSYDRL RFEAGVHRVQ RIPSTETKGR THTSTAAVVV
LPQIGDESAK SIDAYERTFK PGEIRVDIMR ASGKGGQHVN TTDSAVRLTH
IPSGIVVSMQ DERSQHKNKA KAFTILRARL AEKERLEKEE KERKARKSQV
SSTNRSDKIR TYNFPQNRIT DHRCGFTLLD LPGVLSGERL DEVIEAMSKY
DSTERAKELL ESN

Legend

  • X Phoshorylation
  • X Monomethylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[172, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[172, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[179, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[179, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[182, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[182, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[185, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[185, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[287, Mono-CH3]Polevoda, B., Span, L., Sherman, F. (2006). The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p. J Biol Chem 281: 2562-2571. (Publication) (All modifications)