Basic Information

NameMitochondrial glycine transporter YMC1
Uniprot IDP32331
Systematic gene nameYPR058W
Standard gene nameYMC1
Gene namesYMC1 YPR058W YP9499.14
Description from SGDYPR058W YMC1 SGDID:S000006262, Chr XVI from 673751-674674, Genome Release 64-3-1, Verified ORF, "Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication"
Protein length307
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MSEEFPSPQL IDDLEEHPQH DNARVVKDLL AGTAGGIAQV LVGQPFDTTK
VRLQTSSTPT TAMEVVRKLL ANEGPRGFYK GTLTPLIGVG ACVSLQFGVN
EAMKRFFHHR NADMSSTLSL PQYYACGVTG GIVNSFLASP IEHVRIRLQT
QTGSGTNAEF KGPLECIKKL RHNKALLRGL TPTILREGHG CGTYFLVYEA
LIANQMNKRR GLERKDIPAW KLCIFGALSG TALWLMVYPL DVIKSVMQTD
NLQKPKFGNS ISSVAKTLYA NGGIGAFFKG FGPTMLRAAP ANGATFATFE
LAMRLLG

Legend

  • X SUMOylation
  • X K-Succinylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[68, SUMO]Paasch, F., den Brave, F., Psakhye, I., Pfander, B., Jentsch, S. (2018). Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins. J Biol Chem 293: 599-609. (Publication) (All modifications)
[254, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)