Basic Information
| Name | Methionyl-tRNA formyltransferase, mitochondrial (MtFMT) (EC 2.1.2.9) |
| Uniprot ID | P32785 |
| Systematic gene name | YBL013W |
| Standard gene name | FMT1 |
| Gene names | FMT1 YBL013W YBL0311 YBL0313 |
| Description from SGD | YBL013W FMT1 SGDID:S000000109, Chr II from 202056-203261, Genome Release 64-3-1, Verified ORF, "Methionyl-tRNA formyltransferase; catalyzes formylation of mitochondria initiator Met-tRNA and residual cytosolic Met-tRNA due to inefficient translocation into the mitochondrial matrix; starvation or stationary phase entry increases Gcn2p phosphorylation-mediated cytosolic retention of Fmt1p, enhancing N-terminal protein formylation and ultimately N-end rule pathway mediated destruction that involves the Psh1p ubiquitin ligase; potential Cdc28p substrate" |
| Protein length | 401 |
| Download | sequence (fasta, from Uniprot), modifications (csv format) |
| Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MVKMRRITPT RLLFTCRYIS NNASPPVQPL NVLFFGSDTF SNFSLQALNE
LRQNNGSCGI VDNIQVVTRS PKWCGRQKSI LKYPPIFDMA EKLQLPRPIT
CDTKQEMLAL SKLTPSRQGN PENDGSGAPF NAIIAVSFGK LIPGDLIRAV
PLALNVHPSL LPRHKGSAPI QRALLEGDTY TGVTIQTLHP DRFDHGAIVA
QTEPLAIATM LSKGRVNDST ADFNSEGLPR RTAILMDQLG ALGAQLLGQT
LRERLYLPQN RVQAPTAYKP SYAHRITTED KRIHWARDSA AELLNKLETL
GPLHAFKEAT AARKDAQNSV LKRILFHECK VMRDARLDNG SKPGMFKYDD
IKDCILVTCR GNLLLCVSRL QFEGFAVERA GQFMARLRKR CGALSEKLVF
L
LRQNNGSCGI VDNIQVVTRS PKWCGRQKSI LKYPPIFDMA EKLQLPRPIT
CDTKQEMLAL SKLTPSRQGN PENDGSGAPF NAIIAVSFGK LIPGDLIRAV
PLALNVHPSL LPRHKGSAPI QRALLEGDTY TGVTIQTLHP DRFDHGAIVA
QTEPLAIATM LSKGRVNDST ADFNSEGLPR RTAILMDQLG ALGAQLLGQT
LRERLYLPQN RVQAPTAYKP SYAHRITTED KRIHWARDSA AELLNKLETL
GPLHAFKEAT AARKDAQNSV LKRILFHECK VMRDARLDNG SKPGMFKYDD
IKDCILVTCR GNLLLCVSRL QFEGFAVERA GQFMARLRKR CGALSEKLVF
L
Legend
- X Phoshorylation
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
| [167, Phos] | Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications) |