Basic Information

NameMitochondrial chaperone BCS1
Uniprot IDP32839
Systematic gene nameYDR375C
Standard gene nameBCS1
Gene namesBCS1 YDR375C D9481.17
Description from SGDYDR375C BCS1 SGDID:S000002783, Chr IV from 1226536-1225166, Genome Release 64-3-1, reverse complement, Verified ORF, "Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane and delivers it to an assembly intermediate of respiratory Complex III; also required for assembly of the Qcr10p subunit; mutation is functionally complemented by human homolog BCS1L, linked to neonatal diseases"
Protein length456
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MSDKPIDIQY DKQATPNLSG VITPPTNETG NDSVREKLSK LVGDAMSNNP
YFAAGGGLMI LGTGLAVARS GIIKASRVLY RQMIVDLEIQ SKDKSYAWFL
TWMAKHPQRV SRHLSVRTNY IQHDNGSVST KFSLVPGPGN HWIRYKGAFI
LIKRERSAKM IDIANGSPFE TVTLTTLYRD KHLFDDILNE AKDIALKTTE
GKTVIYTSFG PEWRKFGQPK AKRMLPSVIL DSGIKEGILD DVYDFMKNGK
WYSDRGIPYR RGYLLYGPPG SGKTSFIQAL AGELDYNICI LNLSENNLTD
DRLNHLMNNM PERSILLLED IDAAFNKRSQ TGEQGFHSSV TFSGLLNALD
GVTSSEETIT FMTTNHPEKL DAAIMRPGRI DYKVFVGNAT PYQVEKMFMK
FYPGETDICK KFVNSVKELD ITVSTAQLQG LFVMNKDAPH DALKMVSSLR
NANHIF

Legend

  • X Phoshorylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[227, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[227, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)