Basic Information

NameSuccinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial
Uniprot IDP33421
Systematic gene nameYKL141W
Standard gene nameSDH3
Gene namesSDH3 CYB3 YKL141W YKL4
Description from SGDYKL141W SDH3 SGDID:S000001624, Chr XI from 179667-180263, Genome Release 64-3-1, Verified ORF, "Subunit of succinate dehydrogenase and of TIM22 translocase; functions as cytochrome b subunit of succinate dehydrogenase, which couples oxidation of succinate to transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex; SDH3 has a paralog, SHH3, that arose from the whole genome duplication"
Protein length198
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MSAMMVKLGL NKSALLLKPS AFSRAAALSS SRRLLFNTAR TNFLSTSPLK
NVASEMNTKA AIAEEQILNK QRAKRPISPH LTIYQPQLTW YLSSLHRISL
VLMGLGFYLF TILFGVSGLL GLGLTTEKVS NWYHQKFSKI TEWSIKGSFA
YLFAIHYGGA IRHLIWDTAK ELTLKGVYRT GYALIGFTAV LGTYLLTL

Legend

  • X K-Succinylation
  • X SUMOylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[70, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)
[146, SUMO]Paasch, F., den Brave, F., Psakhye, I., Pfander, B., Jentsch, S. (2018). Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins. J Biol Chem 293: 599-609. (Publication) (All modifications)
[175, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)