Basic Information

NameF-box protein COS111 (Ciclopirox olamine sensitivity protein 111)
Uniprot IDP38308
Systematic gene nameYBR203W
Standard gene nameCOS111
Gene namesCOS111 YBR203W YBR1443
Description from SGDYBR203W COS111 SGDID:S000000407, Chr II from 629168-631942, Genome Release 64-3-1, Verified ORF, "Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"
Protein length924
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MSSASRLQNV NIVSNNYSRY GTSVYDKLYH SNGSGSNNAG KNSTTVGKLS
SISQKSRSKQ RHGSNCSRSM SQSPLSTFKS PLSNQNQSSA PDDLASIGQR
RSDDVTSLDN ETIITMNSRK SRIKKKYKSL ISTSSKKFMN KLYDHGASSD
SFSIFSLKTS HSGKHENSRF EKLRKRKYHA WGKFADINDL PVEIIAKILS
EFELGRDQKT LVRCLYVSKK FYKATKIVLY RLPYFTSTYR VAQFVTSLRL
HPDNGAYVKV LDLSHLKPGI IGQDSKDSQG LDDDGHSRRH RRRRRRSTNT
SLNLPPATPT STISNEDDAN SGLIKDDASN GSEVEDLALA GWRDWRYRNE
PLYSSPLLNS FKLKKVVSRS SSITSTSSGN STGVHSTRRQ RSNSSVASIT
TSIMSSIYNT SHVSLSSTTS NTSNGNISSG SNLSRVSTAG SLKKASAKST
RSSPQKAKPI SDITSSSWFR MRLSSRNRKA RTANTINLKN SKDKSDDDFK
VLKHDSGHPS NYRSSTLKFS IEQPFSTHHP YANKFLLKYA PYKDLPLGYI
LHMLNLCPNL VELNLSNLVI CTDFKLINQR SERRRMTSSL LPAVQESSVS
AGPEKDLEIV YMTDSGKGYE YYEGLSKKHS RSSSLGTNPS SWIGGQANWT
DYPPPIDAQT KTREEHRRNN TLNNKNVVLK KLNPFEIFEM ICNRNEEKGG
YCSLTKVKMN DIVWCRQYMV KYFVMRTFRQ HLDYKSMENN SYERHLFSFR
DSGLDRNFSW ACNAKLHEFV ALMVMDHLSN LDDLGLEELF NIKSEKLYIK
NYCCRDPDIL EISNLFDIRY GAGSEADATS DSNLEAESLQ FRLTILKTEK
PTSFWLTKVS KDYVSLVVKL CVDDDIDMDK MKVGKPTLRI DSITHNLISR
LKELRRVDLR RNVGENNYYA ESII

Legend

  • X Phoshorylation
  • X Ubiquitination

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[134, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[143, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[143, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[148, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[148, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[149, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[149, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[151, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[151, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[458, Ubi]Swaney, D.L.,  Beltrao, P.,  Starita, L.,  Guo, A.,  Rush, J.,  Fields, S.,  Krogan, N.J.,  Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications)
[588, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[588, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[589, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[589, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)