Basic Information

NameSerine--tRNA ligase, mitochondrial (EC 6.1.1.11) (Digs into agar protein 4) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)
Uniprot IDP38705
Systematic gene nameYHR011W
Standard gene nameDIA4
Gene namesDIA4 YHR011W
Description from SGDYHR011W DIA4 SGDID:S000001053, Chr VIII from 127780-129120, Genome Release 64-3-1, Verified ORF, "Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth"
Protein length446
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MIIRRLFSIS NRSFFLKKPQ FDVKKIIEMI PQYQTSIQNR ELIEADSIIR
SLQLLGERYQ NIKEIDKVIA DIQIQRKSIE AQIKKDKTKI TEYSAALKAL
KEQYNDQNSK SSELKKKILE TCKSLPNTLD PTVPLDAPQI EQWINPLKTH
KTSEAQAHVD IMLKKNMLDL QTASNVTGMS WYYLLNDGAR LEQALVAYAL
KKANENGFSS CVPPSITKKE LIDACGFNPR DMNNERQIYA LQDTNLGLVA
TAEIPLAGLG ANKVLELNSG ECSKKLVGVS RCYRAEAGAR GKDTKGLYRV
HEFTKVELFC WSKPETSAKV LEEIKQFQIS VVEELGIPAK VLNMPSNDLG
NPAFKKYDIE AWMPGRGKFG EISSASNCTD FQSRRLNTKY RDDNTGKLEY
VHTLNGTAMA IPRVIVALVE NFYDPSTGKI SVPECLREFM NGQRYI

Legend

  • X Monomethylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[290, Mono-CH3]Low, J.K.,  Im, H.,  Erce, M.A.,  Hart-Smith, G.,  Snyder, M.P.,  Wilkins, M.R. (2016). Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays. Proteomics 16: 465-476. (Publication) (All modifications)