Basic Information

NameFamily of serine hydrolases 1 (EC 3.1.-.-)
Uniprot IDP38777
Systematic gene nameYHR049W
Standard gene nameFSH1
Gene namesFSH1 YHR049W
Description from SGDYHR049W FSH1 SGDID:S000001091, Chr VIII from 206462-207193, Genome Release 64-3-1, Verified ORF, "Lysophospholipase; hydrolyzes lysophosphatidylserine to release free fatty acid; involved in regulated cell death; localizes to both the nucleus and cytoplasm; contains a catalytic triad of Ser-His-Asp that is part of an alpha/beta hydrolase fold and a lipase motif (GXSXG); sequence similarity to Fsh2p and Fsh3p and the human candidate tumor suppressor and serine hydrolase, OVCA2"
Protein length243
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MTVQIPKLLF LHGFLQNGKV FSEKSSGIRK LLKKANVQCD YIDAPVLLEK
KDLPFEMDDE KWQATLDADV NRAWFYHSEI SHELDISEGL KSVVDHIKAN
GPYDGIVGFS QGAALSSIIT NKISELVPDH PQFKVSVVIS GYSFTEPDPE
HPGELRITEK FRDSFAVKPD MKTKMIFIYG ASDQAVPSVR SKYLYDIYLK
AQNGNKEKVL AYEHPGGHMV PNKKDIIRPI VEQITSSLQE ASE

Legend

  • X K-acetylation
  • X Phoshorylation
  • X Ubiquitination

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[24, K-acetyl]Henriksen, P., Wagner, S. A., Weinert, B. T., et al. (2012). Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Molecular & Cellular Proteomics, 11(11), 1510-1522. (Publication) (All modifications)
[92, Phos]Zhou, X., Li, W., Liu, Y., Amon, A. (2021. Cross-compartment signal propagation in the mitotic exit network. Elife 10:e63645. (Publication) (All modifications)
[122, Ubi]Swaney, D.L.,  Beltrao, P.,  Starita, L.,  Guo, A.,  Rush, J.,  Fields, S.,  Krogan, N.J.,  Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications)
[124, Phos]Zhou, X., Li, W., Liu, Y., Amon, A. (2021. Cross-compartment signal propagation in the mitotic exit network. Elife 10:e63645. (Publication) (All modifications)
[164, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)