Basic Information
Name | Family of serine hydrolases 1 (EC 3.1.-.-) |
Uniprot ID | P38777 |
Systematic gene name | YHR049W |
Standard gene name | FSH1 |
Gene names | FSH1 YHR049W |
Description from SGD | YHR049W FSH1 SGDID:S000001091, Chr VIII from 206462-207193, Genome Release 64-3-1, Verified ORF, "Lysophospholipase; hydrolyzes lysophosphatidylserine to release free fatty acid; involved in regulated cell death; localizes to both the nucleus and cytoplasm; contains a catalytic triad of Ser-His-Asp that is part of an alpha/beta hydrolase fold and a lipase motif (GXSXG); sequence similarity to Fsh2p and Fsh3p and the human candidate tumor suppressor and serine hydrolase, OVCA2" |
Protein length | 243 |
Download | sequence (fasta, from Uniprot), modifications (csv format) |
Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MTVQIPKLLF LHGFLQNGKV FSEKSSGIRK LLKKANVQCD YIDAPVLLEK
KDLPFEMDDE KWQATLDADV NRAWFYHSEI SHELDISEGL KSVVDHIKAN
GPYDGIVGFS QGAALSSIIT NKISELVPDH PQFKVSVVIS GYSFTEPDPE
HPGELRITEK FRDSFAVKPD MKTKMIFIYG ASDQAVPSVR SKYLYDIYLK
AQNGNKEKVL AYEHPGGHMV PNKKDIIRPI VEQITSSLQE ASE
KDLPFEMDDE KWQATLDADV NRAWFYHSEI SHELDISEGL KSVVDHIKAN
GPYDGIVGFS QGAALSSIIT NKISELVPDH PQFKVSVVIS GYSFTEPDPE
HPGELRITEK FRDSFAVKPD MKTKMIFIYG ASDQAVPSVR SKYLYDIYLK
AQNGNKEKVL AYEHPGGHMV PNKKDIIRPI VEQITSSLQE ASE
Legend
- X K-acetylation
- X Phoshorylation
- X Ubiquitination
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
[24, K-acetyl] | Henriksen, P., Wagner, S. A., Weinert, B. T., et al. (2012). Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Molecular & Cellular Proteomics, 11(11), 1510-1522. (Publication) (All modifications) |
[92, Phos] | Zhou, X., Li, W., Liu, Y., Amon, A. (2021. Cross-compartment signal propagation in the mitotic exit network. Elife 10:e63645. (Publication) (All modifications) |
[122, Ubi] | Swaney, D.L., Beltrao, P., Starita, L., Guo, A., Rush, J., Fields, S., Krogan, N.J., Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications) |
[124, Phos] | Zhou, X., Li, W., Liu, Y., Amon, A. (2021. Cross-compartment signal propagation in the mitotic exit network. Elife 10:e63645. (Publication) (All modifications) |
[164, Phos] | Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications) |