Basic Information
Name | Mitochondrial Rho GTPase 1 (EC 3.6.5.-) (GTPase EF-hand protein of mitochondria 1) |
Uniprot ID | P39722 |
Systematic gene name | YAL048C |
Standard gene name | GEM1 |
Gene names | GEM1 YAL048C |
Description from SGD | YAL048C GEM1 SGDID:S000000046, Chr I from 54789-52801, Genome Release 64-3-1, reverse complement, Verified ORF, "Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases" |
Protein length | 662 |
Download | sequence (fasta, from Uniprot), modifications (csv format) |
Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MTKETIRVVI CGDEGVGKSS LIVSLTKAEF IPTIQDVLPP ISIPRDFSSS
PTYSPKNTVL IDTSDSDLIA LDHELKSADV IWLVYCDHES YDHVSLFWLP
HFRSLGLNIP VILCKNKCDS ISNVNANAMV VSENSDDDID TKVEDEEFIP
ILMEFKEIDT CIKTSAKTQF DLNQAFYLCQ RAITHPISPL FDAMVGELKP
LAVMALKRIF LLSDLNQDSY LDDNEILGLQ KKCFNKSIDV NELNFIKDLL
LDISKHDQEY INRKLYVPGK GITKDGFLVL NKIYAERGRH ETTWAILRTF
HYTDSLCIND KILHPRLVVP DTSSVELSPK GYRFLVDIFL KFDIDNDGGL
NNQELHRLFK CTPGLPKLWT STNFPFSTVV NNKGCITLQG WLAQWSMTTF
LNYSTTTAYL VYFGFQEDAR LALQVTKPRK MRRRSGKLYR SNINDRKVFN
CFVIGKPCCG KSSLLEAFLG RSFSEEYSPT IKPRIAVNSL ELKGGKQYYL
ILQELGEQEY AILENKDKLK ECDVICLTYD SSDPESFSYL VSLLDKFTHL
QDLPLVFVAS KADLDKQQQR CQIQPDELAD ELFVNHPLHI SSRWLSSLNE
LFIKITEAAL DPGKNTPGLP EETAAKDVDY RQTALIFGST VGFVALCSFT
LMKLFKSSKF SK
PTYSPKNTVL IDTSDSDLIA LDHELKSADV IWLVYCDHES YDHVSLFWLP
HFRSLGLNIP VILCKNKCDS ISNVNANAMV VSENSDDDID TKVEDEEFIP
ILMEFKEIDT CIKTSAKTQF DLNQAFYLCQ RAITHPISPL FDAMVGELKP
LAVMALKRIF LLSDLNQDSY LDDNEILGLQ KKCFNKSIDV NELNFIKDLL
LDISKHDQEY INRKLYVPGK GITKDGFLVL NKIYAERGRH ETTWAILRTF
HYTDSLCIND KILHPRLVVP DTSSVELSPK GYRFLVDIFL KFDIDNDGGL
NNQELHRLFK CTPGLPKLWT STNFPFSTVV NNKGCITLQG WLAQWSMTTF
LNYSTTTAYL VYFGFQEDAR LALQVTKPRK MRRRSGKLYR SNINDRKVFN
CFVIGKPCCG KSSLLEAFLG RSFSEEYSPT IKPRIAVNSL ELKGGKQYYL
ILQELGEQEY AILENKDKLK ECDVICLTYD SSDPESFSYL VSLLDKFTHL
QDLPLVFVAS KADLDKQQQR CQIQPDELAD ELFVNHPLHI SSRWLSSLNE
LFIKITEAAL DPGKNTPGLP EETAAKDVDY RQTALIFGST VGFVALCSFT
LMKLFKSSKF SK
Legend
- X Phoshorylation
- X Ubiquitination
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
[50, Phos] | Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications) |
[53, Phos] | Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications) |
[54, Phos] | Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications) |
[54, Phos] | Renvoisé M, Bonhomme L, Davanture M, et al (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. Journal of Proteomics 106:140–150. (Publication) (All modifications) |
[54, Phos] | Swaney, D.L., Beltrao, P., Starita, L., Guo, A., Rush, J., Fields, S., Krogan, N.J., Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications) |
[54, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |
[482, Ubi] | Swaney, D.L., Beltrao, P., Starita, L., Guo, A., Rush, J., Fields, S., Krogan, N.J., Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications) |
[493, Ubi] | Swaney, D.L., Beltrao, P., Starita, L., Guo, A., Rush, J., Fields, S., Krogan, N.J., Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications) |
[566, Ubi] | Swaney, D.L., Beltrao, P., Starita, L., Guo, A., Rush, J., Fields, S., Krogan, N.J., Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications) |