Basic Information

NameBolA-like protein 3 (Altered inheritance of mitochondria protein 1)
Uniprot IDP39724
Systematic gene nameYAL046C
Standard gene nameBOL3
Gene namesBOL3 AIM1 YAL046C
Description from SGDYAL046C BOL3 SGDID:S000000044, Chr I from 57385-57029, Genome Release 64-3-1, reverse complement, Verified ORF, "Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress by acting along with Nfu1p at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to mitochondrial client proteins like lipoate synthase and succinate dehydrogenase; sequence similarity to human BOLA family member, BOLA3, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS2)"
Protein length118
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MKLPQTMLRS ISVKHVRWPR ILTGSKLWYS TQMAMTPEEK MITDKLQQEL
EPEVCKVQDV SGGCGSMFAI NITSKKFNGL SLIKQHQLVN RILRDDISRW
HGLQLTTKKS TGKGPASS

Legend

  • X K-Succinylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[108, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)