Basic Information

NameIntermediate cleaving peptidase 55 (EC 3.4.11.26) (Intermediate cleaving peptidase of 55 kDa)
Uniprot IDP40051
Systematic gene nameYER078C
Standard gene nameICP55
Gene namesICP55 YER078C
Description from SGDYER078C ICP55 SGDID:S000000880, Chr V from 318342-316807, Genome Release 64-3-1, reverse complement, Verified ORF, "Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family; yeast ortholog of human gene XPNPEP3, which is mutated in rare hereditary kidney disease similar to nephronophthisis"
Protein length511
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MLHRINPVRF SMQSCQRYFS KLVSPLEQHK SNTFTNRVRI PIEAGQPLHE
TRPFLIKSGE LTPGISALEY YERRIRLAET LPPKSCVILA GNDIQFASGA
VFYPFQQEND LFYLSGWNEP NSVMILEKPT DSLSDTIFHM LVPPKDAFAE
KWEGFRSGVY GVQEIFNADE SASINDLSKY LPKIINRNDF IYFDMLSTSN
PSSSNFKHIK SLLDGSGNSN RSLNSIANKT IKPISKRIAE FRKIKSPQEL
RIMRRAGQIS GRSFNQAFAK RFRNERTLDS FLHYKFISGG CDKDAYIPVV
ATGSNSLCIH YTRNDDVMFD DEMVLVDAAG SLGGYCADIS RTWPNSGKFT
DAQRDLYEAV LNVQRDCIKL CKASNNYSLH DIHEKSITLM KQELKNLGID
KVSGWNVEKL YPHYIGHNLG LDVHDVPKVS RYEPLKVGQV ITIEPGLYIP
NEESFPSYFR NVGIRIEDDI AIGEDTYTNL TVEAVKEIDD LENVMQNGLS
TKFEEDQVAP L

Legend

  • X K-Succinylation
  • X Phoshorylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


Use imported representation

Loading structure from server... It may take a while.

If you believe something went wrong, please make sure PDB ID is correct.
Please also make sure that WebGL is enabled in your browser.

References

[183, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)
[216, Phos]Renvoisé M, Bonhomme L, Davanture M, et al (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. Journal of Proteomics 106:140–150. (Publication) (All modifications)
[216, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[219, Phos]Renvoisé M, Bonhomme L, Davanture M, et al (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. Journal of Proteomics 106:140–150. (Publication) (All modifications)
[219, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[236, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)
[270, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)
[391, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)