Basic Information
Name | Cytochrome c oxidase assembly protein COX15 |
Uniprot ID | P40086 |
Systematic gene name | YER141W |
Standard gene name | COX15 |
Gene names | COX15 YER141W |
Description from SGD | YER141W COX15 SGDID:S000000943, Chr V from 453459-454919, Genome Release 64-3-1, Verified ORF, "Heme a synthase; required for the hydroxylation of heme O to form heme A, an essential prosthetic group for cytochrome c oxidase; oligomerization is required for function" |
Protein length | 486 |
Download | sequence (fasta, from Uniprot), modifications (csv format) |
Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MLFRNIEVGR QAAKLLTRTS SRLAWQSIGA SRNISTIRQQ IRKTQLYNFK
KTVSIRPFSL SSPVFKPHVA SESNPIESRL KTSKNVAYWL IGTSGLVFGI
VVLGGLTRLT ESGLSITEWK PVTGTLPPMN QKEWEEEFIK YKESPEFKLL
NSHIDLDEFK FIFFMEWIHR LWGRAIGAVF ILPAVYFAVS KKTSGHVNKR
LFGLAGLLGL QGFVGWWMVK SGLDQEQLDA RKSKPTVSQY RLTTHLGTAF
FLYMGMLWTG LEILRECKWI KNPVQAISLF KKLDNPAIGP MRKISLALLA
VSFLTAMSGG MVAGLDAGWV YNTWPKMGER WFPSSRELMD ENFCRREDKK
DLWWRNLLEN PVTVQLVHRT CAYVAFTSVL AAHMYAIKKK AVIPRNAMTS
LHVMMGVVTL QATLGILTIL YLVPISLASI HQAGALALLT SSLVFASQLR
KPRAPMRNVI ITLPHSSKVT SGKILSEASK LASKPL
KTVSIRPFSL SSPVFKPHVA SESNPIESRL KTSKNVAYWL IGTSGLVFGI
VVLGGLTRLT ESGLSITEWK PVTGTLPPMN QKEWEEEFIK YKESPEFKLL
NSHIDLDEFK FIFFMEWIHR LWGRAIGAVF ILPAVYFAVS KKTSGHVNKR
LFGLAGLLGL QGFVGWWMVK SGLDQEQLDA RKSKPTVSQY RLTTHLGTAF
FLYMGMLWTG LEILRECKWI KNPVQAISLF KKLDNPAIGP MRKISLALLA
VSFLTAMSGG MVAGLDAGWV YNTWPKMGER WFPSSRELMD ENFCRREDKK
DLWWRNLLEN PVTVQLVHRT CAYVAFTSVL AAHMYAIKKK AVIPRNAMTS
LHVMMGVVTL QATLGILTIL YLVPISLASI HQAGALALLT SSLVFASQLR
KPRAPMRNVI ITLPHSSKVT SGKILSEASK LASKPL
Legend
- X K-Succinylation
- X Multiple modifications
- X Phoshorylation
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
[142, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[271, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[281, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[281, K-acetyl] | Henriksen, P., Wagner, S. A., Weinert, B. T., et al. (2012). Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Molecular & Cellular Proteomics, 11(11), 1510-1522. (Publication) (All modifications) |
[282, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[467, Phos] | Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications) |
[467, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |
[468, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[473, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[476, Phos] | Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications) |
[480, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |