Basic Information

NameProtein N-terminal amidase (NT-amidase) (EC 3.5.1.-)
Uniprot IDP40354
Systematic gene nameYJR062C
Standard gene nameNTA1
Gene namesNTA1 YJR062C J1742
Description from SGDYJR062C NTA1 SGDID:S000003823, Chr X from 554849-553476, Genome Release 64-3-1, reverse complement, Verified ORF, "Amidase; removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation"
Protein length457
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MLIDAIHGAK MSTKLLVSLK VLVIQLNPQI GQVDQTIKRT WSILDKVTKS
ATYVKPDIIL FPEFALTGYS FHARKDILPY VTKKDEGPSF ELAKSISEKF
QCYTIIGYPE DDDEQKLYNS ALVVNPQGEQ IFNYRKTFLY DTEMNWDCEE
NPEGFQTFPM DFSKCAKLSN EDSYNRDVTL KASIGICMDL SPYKFMAPFN
HFEFSSFCVD NNVELILCPM AWLNSTSITD KQTLHNNSLL EAAKNKIAFA
LKEQGLPLAG SQGIYQLKIG DSQRTPRVPS DDSTSEYKDM DEPDMSNVNY
WILRFFPFLY FKSRINWFKN SSLIESILGK TRMPLDHEYY KDGKHKEDTI
DLLDSEEVIK DTVLEKTFLG TSLGQPWKFQ GKNAILVLAN RCGTEDGTTI
FAGSSGIYKF NGKKPKGSQD DDESSLDSLN ESVELLGNLG KGLEGAILRE
VQFEVFR

Legend

  • X Phoshorylation
  • X Ubiquitination

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[18, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[18, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[42, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[285, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[319, Ubi]Swaney, D.L.,  Beltrao, P.,  Starita, L.,  Guo, A.,  Rush, J.,  Fields, S.,  Krogan, N.J.,  Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications)