Basic Information
| Name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial (PDK 1) (Pyruvate dehydrogenase kinase 1) (EC 2.7.11.2) (Protein kinase of PDH protein 1) (Pyruvate dehydrogenase complex kinase 1) (PDC kinase 1) ([Pyruvate dehydrogenase [lipoamide]] kinase 1) |
| Uniprot ID | P40530 |
| Systematic gene name | YIL042C |
| Standard gene name | PKP1 |
| Gene names | PKP1 YIL042C |
| Description from SGD | YIL042C PKP1 SGDID:S000001304, Chr IX from 276292-275108, Genome Release 64-3-1, reverse complement, Verified ORF, "Mitochondrial protein kinase; involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p" |
| Protein length | 394 |
| Download | sequence (fasta, from Uniprot), modifications (csv format) |
| Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MWKIMRSWKC GGMRWAHRQR PSHELLSQLS FDQHYKIRSN IELLIQDYAS
KPIAPLNYEY FLQYRPPLTK KEEYMLTIKT INLLLSLTCK RLNAIQRLPY
NAVINPHIER TNSLYLKSLQ TLLSIAYPYE LHNPPKIQAK FTELLDDHED
AIVVLAKGLQ EIQSCYPKFQ ISQFLNFHLK ERITMKLLVT HYLSLMAQNK
GDTNKRMIGI LHRDLPIAQL IKHVSDYVND ICFVKFNTQR TPVLIHPPSQ
DITFTCIPPI LEYIMTEVFK NAFEAQIALG KEHMPIEINL LKPDDDELYL
RIRDHGGGIT PEVEALMFNY SYSTHTQQSA DSESTDLPGE QINNVSGMGF
GLPMCKTYLE LFGGKIDVQS LLGWGTDVYI KLKGPSKTAL LSKK
KPIAPLNYEY FLQYRPPLTK KEEYMLTIKT INLLLSLTCK RLNAIQRLPY
NAVINPHIER TNSLYLKSLQ TLLSIAYPYE LHNPPKIQAK FTELLDDHED
AIVVLAKGLQ EIQSCYPKFQ ISQFLNFHLK ERITMKLLVT HYLSLMAQNK
GDTNKRMIGI LHRDLPIAQL IKHVSDYVND ICFVKFNTQR TPVLIHPPSQ
DITFTCIPPI LEYIMTEVFK NAFEAQIALG KEHMPIEINL LKPDDDELYL
RIRDHGGGIT PEVEALMFNY SYSTHTQQSA DSESTDLPGE QINNVSGMGF
GLPMCKTYLE LFGGKIDVQS LLGWGTDVYI KLKGPSKTAL LSKK
Legend
- X SUMOylation
- X Phoshorylation
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
| [3, SUMO] | Paasch, F., den Brave, F., Psakhye, I., Pfander, B., Jentsch, S. (2018). Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins. J Biol Chem 293: 599-609. (Publication) (All modifications) |
| [388, Phos] | Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications) |
| [388, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |