P41808

Name	Sporulation-specific mitogen-activated protein kinase SMK1 (MAP kinase SMK1) (EC 2.7.11.24)
Uniprot ID	P41808
Systematic gene name	YPR054W
Standard gene name	SMK1
Gene names	SMK1 YPR054W YP9499.10
Description from SGD	YPR054W SMK1 SGDID:S000006258, Chr XVI from 666280-667446, Genome Release 64-3-1, Verified ORF, "Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for prospore membrane development and the production of outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p; activated by Cak1p-mediated phosphorylation of threonine (T207) in the activation loop during meiosis I followed by Ssp2p-promoted autophosphorylation of tyrosine (T209) during meiosis II"
Protein length	388
Download	sequence (fasta, from Uniprot), modifications (csv format)
Database links	Uniprot, SGD, TheCellVision.org, FungiDB

MNCTLTDNTR AINVASNLGA PQQRTIFAKE RISIPGYYEI IQFLGKGAYG
TVCSVKFKGR SPAARIAVKK ISNIFNKEIL LKRAIRELKF MNFFKGHKNI
VNLIDLEIVT SSPYDGLYCY QELIDYDLAK VIHSSVQLSE FHIKYFLYQI
LCGLKYIHSA DVIHRDLKPG NILCTLNGCL KICDFGLARG IHAGFFKCHS
TVQPHITNYV ATRWYRAPEL LLSNQPYSKS VDIWAVGCIL AEFYARKPVF
MGRDSMHQIF EIIKVLGTPD KDILIKFGTI KAWNLGKNSN NPVYKKIPWS
NIFPFASHEA INLIESLLHW DSTHRLNVEQ AISHPFLNEV RKPDDEPVCL
QGPFDFTYES ELNSMSKLRD YLVEEVKNFK TDLSSSSL

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[207, Phos]	Rimal, A.,  Kamdar, Z.P.,  Tio, C.W.,  Winter, E. (2020). Isc10, an inhibitor that links the anaphase-promoting complex to a meiosis-specific mitogen-activated protein kinase. Mol Cell Biol 40: e00097-20. (Publication) (All modifications)
[207, Phos]	Omerza, G.,  Tio, C.W.,  Philips, T.,  Diamond, A.,  Neiman, A.M.,  Winter, E. (2018). The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. Mol Biol Cell 29: 66-74. (Publication) (All modifications)
[209, Phos]	Rimal, A.,  Kamdar, Z.P.,  Tio, C.W.,  Winter, E. (2020). Isc10, an inhibitor that links the anaphase-promoting complex to a meiosis-specific mitogen-activated protein kinase. Mol Cell Biol 40: e00097-20. (Publication) (All modifications)
[209, Phos]	Omerza, G.,  Tio, C.W.,  Philips, T.,  Diamond, A.,  Neiman, A.M.,  Winter, E. (2018). The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. Mol Biol Cell 29: 66-74. (Publication) (All modifications)