Basic Information
| Name | Translation factor GUF1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase GUF1) (Ribosomal back-translocase) |
| Uniprot ID | P46943 |
| Systematic gene name | YLR289W |
| Standard gene name | GUF1 |
| Gene names | GUF1 YLR289W L8003.7 |
| Description from SGD | YLR289W GUF1 SGDID:S000004280, Chr XII from 715089-717026, Genome Release 64-3-1, Verified ORF, "Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor" |
| Protein length | 645 |
| Download | sequence (fasta, from Uniprot), modifications (csv format) |
| Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MLKFRIRPVR HIRCYKRHAY FLRYNHTTTP AQKLQAQIEQ IPLENYRNFS
IVAHVDHGKS TLSDRLLEIT HVIDPNARNK QVLDKLEVER ERGITIKAQT
CSMFYKDKRT GKNYLLHLID TPGHVDFRGE VSRSYASCGG AILLVDASQG
IQAQTVANFY LAFSLGLKLI PVINKIDLNF TDVKQVKDQI VNNFELPEED
IIGVSAKTGL NVEELLLPAI IDRIPPPTGR PDKPFRALLV DSWYDAYLGA
VLLVNIVDGS VRKNDKVICA QTKEKYEVKD IGIMYPDRTS TGTLKTGQVG
YLVLGMKDSK EAKIGDTIMH LSKVNETEVL PGFEEQKPMV FVGAFPADGI
EFKAMDDDMS RLVLNDRSVT LERETSNALG QGWRLGFLGS LHASVFRERL
EKEYGSKLII TQPTVPYLVE FTDGKKKLIT NPDEFPDGAT KRVNVAAFHE
PFIEAVMTLP QEYLGSVIRL CDSNRGEQID ITYLNTNGQV MLKYYLPLSH
LVDDFFGKLK SVSRGFASLD YEDAGYRISD VVKLQLLVNG NAIDALSRVL
HKSEVERVGR EWVKKFKEYV KSQLYEVVIQ ARANNKIIAR ETIKARRKDV
LQKLHASDVS RRKKLLAKQK EGKKHMKTVG NIQINQEAYQ AFLRR
IVAHVDHGKS TLSDRLLEIT HVIDPNARNK QVLDKLEVER ERGITIKAQT
CSMFYKDKRT GKNYLLHLID TPGHVDFRGE VSRSYASCGG AILLVDASQG
IQAQTVANFY LAFSLGLKLI PVINKIDLNF TDVKQVKDQI VNNFELPEED
IIGVSAKTGL NVEELLLPAI IDRIPPPTGR PDKPFRALLV DSWYDAYLGA
VLLVNIVDGS VRKNDKVICA QTKEKYEVKD IGIMYPDRTS TGTLKTGQVG
YLVLGMKDSK EAKIGDTIMH LSKVNETEVL PGFEEQKPMV FVGAFPADGI
EFKAMDDDMS RLVLNDRSVT LERETSNALG QGWRLGFLGS LHASVFRERL
EKEYGSKLII TQPTVPYLVE FTDGKKKLIT NPDEFPDGAT KRVNVAAFHE
PFIEAVMTLP QEYLGSVIRL CDSNRGEQID ITYLNTNGQV MLKYYLPLSH
LVDDFFGKLK SVSRGFASLD YEDAGYRISD VVKLQLLVNG NAIDALSRVL
HKSEVERVGR EWVKKFKEYV KSQLYEVVIQ ARANNKIIAR ETIKARRKDV
LQKLHASDVS RRKKLLAKQK EGKKHMKTVG NIQINQEAYQ AFLRR
Legend
- X SUMOylation
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
| [508, SUMO] | Paasch, F., den Brave, F., Psakhye, I., Pfander, B., Jentsch, S. (2018). Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins. J Biol Chem 293: 599-609. (Publication) (All modifications) |