Basic Information

NamePhosphatidylinositol transfer protein SFH5 (PITP SFH5) (SEC14 homolog 5)
Uniprot IDP47008
Systematic gene nameYJL145W
Standard gene nameSFH5
Gene namesSFH5 YJL145W J0644
Description from SGDYJL145W SFH5 SGDID:S000003681, Chr X from 145160-146044, Genome Release 64-3-1, Verified ORF, "Unusual phosphatidylinositol transfer protein (PITP) that binds heme; similar to Sec14p; founding member of conserved class of fungal hemoproteins; exhibits PI- but not PC-transfer activity; localizes to peripheral endoplasmic reticulum, cytosol, and microsomes; partially relocalizes to plasma membrane upon DNA replication stress"
Protein length294
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MKFDNDSEKQ VFDKLKKAIP GIIKEKCAGY DELYGYKLNP EGLTQEEVDK
YYDEKIADRL TYKLCKAYQF EYSTIVQNLI DILNWRREFN PLSCAYKEVH
NTELQNVGIL TFDANGDANK KAVTWNLYGQ LVKKKELFQN VDKFVRYRIG
LMEKGLSLLD FTSSDNNYMT QVHDYKGVSV WRMDSDIKNC SKTVIGIFQK
YYPELLYAKY FVNVPTVFGW VYDLIKKFVD ETTRKKFVVL TDGSKLGQYL
KDCPYEGYGG KDKKNNLTKQ NVTNVHPTEY GLYILQKQII EDVE

Legend

  • X Ubiquitination

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[17, Ubi]Back, S., Gorman, A.W., Vogel, C., Silva, G.M. (2019). Site-specific K63 ubiquitinomics provides insights into translation regulation under stress. Journal of Proteome Research 18(1): 309-318. (Publication) (All modifications)
[17, Ubi]Swaney, D.L.,  Beltrao, P.,  Starita, L.,  Guo, A.,  Rush, J.,  Fields, S.,  Krogan, N.J.,  Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications)
[50, Ubi]Swaney, D.L.,  Beltrao, P.,  Starita, L.,  Guo, A.,  Rush, J.,  Fields, S.,  Krogan, N.J.,  Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications)