Basic Information

NameApoptosis-inducing factor 1 (EC 1.-.-.-) (Cercosporin and photosensitizer-detoxification protein 1)
Uniprot IDP52923
Systematic gene nameYNR074C
Standard gene nameAIF1
Gene namesAIF1 CPD1 YNR074C N3815
Description from SGDYNR074C AIF1 SGDID:S000005357, Chr XIV from 778738-777602, Genome Release 64-3-1, reverse complement, Verified ORF, "Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli; triggers apoptosis in cells lacking HXK2; homolog of mammalian Apoptosis-Inducing Factor, putative reductase"
Protein length378
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MTINTKNIVV VGAGVFGVSV ANHLYRELGG TYAIKLVTAS NYVYFLPSAV
RLTVSKDYTK SILPLKNVLD SGIEVIKDTA ASFDDKEVVL GSDRAIKFDI
LVLATGSKWA DPIGSTYTFG DNYKEYFERE ASRISDADHI LFLGGGFVNC
ELAGELLFKY LEEIRSGKKR ISIIHNSDKL LPDSGLYNDT LRKNVTDYLS
KNGITLYLNT VGASLDTSPK RIFLGEGSSK YIDADLIYRG VGISPNVPVN
SISDLCDKKG FIQVEKNFRV KAVEAGNVFA IGDVTNFRYH GLVKRDNWVD
VLTRNVISSL QEGTEASLVD ADCLETGHAP SGVSLGPNAG FGQFPLPLLG
TINIPSFLIS RAKSKNLFSD KMEPLFKK

Legend

  • X Phoshorylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[218, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[228, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[229, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[364, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[364, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)