Basic Information

NametRNA pseudouridine(31) synthase (EC 5.4.99.42) (Pseudouridine synthase 6) (Pseudouridylate synthase 6) (Uracil hydrolyase) (tRNA pseudouridine 31 synthase) (PSI31 synthase)
Uniprot IDP53294
Systematic gene nameYGR169C
Standard gene namePUS6
Gene namesPUS6 YGR169C
Description from SGDYGR169C PUS6 SGDID:S000003401, Chr VII from 835903-834689, Genome Release 64-3-1, reverse complement, Verified ORF, "tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability"
Protein length404
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MSTIKVIEVY TQNGLRKVRP YYNRRSAFVK GRWLGKLLID VLVSEFKLRP
RAYYLDQIRK GTYRLIRDGV PLVPDHLMTT IIKNHDVLET TTHKHEPPVK
QWCSQEVEAE DLPGRIAGFN IVFEDESILV IDKPSGIPVH PTGQFYQNTI
TELLKLHGVD ALPCYRLDKI TSGLLILAKN SQSAGEIQKS IRSRDMIKIY
LARVKGRFPH SELILDNENA AETTFEDTSK VTVEMTPIYS IDPKRQFPVG
LSTSKDAITK FYPIRYFSHA DETVVACKPI TGRTHQIRIH LARLGHPIVN
DSVYCSHITK YPERLKFITQ FPRWENQQDL DAEELKVRFQ KFVDETKNNC
RTMETFCPEC HTVDLKDPVL SDLELWLHAW KYEEINGKFK FKTDLPKWAQ
LDNS

Legend

  • X Phoshorylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[183, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[273, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[273, Phos]Albuquerque, C.P., Smolka, M.B., Payne, S.H., Bafna, V., Eng, J., Zhou, H. (2008). A multidimensional chromatography technology for in-depth phosphoproteome analysis. Molecular and Cellular Proteomics 7(7):1389-1396. (Publication) (All modifications)
[273, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)