Basic Information
Name | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Ubiquinone C4-deaminase) (EC 3.5.-.-) |
Uniprot ID | P53318 |
Systematic gene name | YGR255C |
Standard gene name | COQ6 |
Gene names | COQ6 YGR255C G9165 |
Description from SGD | YGR255C COQ6 SGDID:S000003487, Chr VII from 1003962-1002523, Genome Release 64-3-1, reverse complement, Verified ORF, "Flavin-dependent monooxygenase involved in ubiquinone biosynthesis; responsible for hydroxylation at position C5 and deamination at C4 during ubiquinone (Coenzyme Q) biosynthesis; localizes to matrix face of mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human homolog COQ6 can complement yeast null mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)" |
Protein length | 479 |
Download | sequence (fasta, from Uniprot), modifications (csv format) |
Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MFFSKVMLTR RILVRGLATA KSSAPKLTDV LIVGGGPAGL TLAASIKNSP
QLKDLKTTLV DMVDLKDKLS DFYNSPPDYF TNRIVSVTPR SIHFLENNAG
ATLMHDRIQS YDGLYVTDGC SKATLDLARD SMLCMIEIIN IQASLYNRIS
QYDSKKDSID IIDNTKVVNI KHSDPNDPLS WPLVTLSNGE VYKTRLLVGA
DGFNSPTRRF SQIPSRGWMY NAYGVVASMK LEYPPFKLRG WQRFLPTGPI
AHLPMPENNA TLVWSSSERL SRLLLSLPPE SFTALINAAF VLEDADMNYY
YRTLEDGSMD TDKLIEDIKF RTEEIYATLK DESDIDEIYP PRVVSIIDKT
RARFPLKLTH ADRYCTDRVA LVGDAAHTTH PLAGQGLNMG QTDVHGLVYA
LEKAMERGLD IGSSLSLEPF WAERYPSNNV LLGMADKLFK LYHTNFPPVV
ALRTFGLNLT NKIGPVKNMI IDTLGGNEK
QLKDLKTTLV DMVDLKDKLS DFYNSPPDYF TNRIVSVTPR SIHFLENNAG
ATLMHDRIQS YDGLYVTDGC SKATLDLARD SMLCMIEIIN IQASLYNRIS
QYDSKKDSID IIDNTKVVNI KHSDPNDPLS WPLVTLSNGE VYKTRLLVGA
DGFNSPTRRF SQIPSRGWMY NAYGVVASMK LEYPPFKLRG WQRFLPTGPI
AHLPMPENNA TLVWSSSERL SRLLLSLPPE SFTALINAAF VLEDADMNYY
YRTLEDGSMD TDKLIEDIKF RTEEIYATLK DESDIDEIYP PRVVSIIDKT
RARFPLKLTH ADRYCTDRVA LVGDAAHTTH PLAGQGLNMG QTDVHGLVYA
LEKAMERGLD IGSSLSLEPF WAERYPSNNV LLGMADKLFK LYHTNFPPVV
ALRTFGLNLT NKIGPVKNMI IDTLGGNEK
Legend
- X K-Succinylation
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
[166, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[349, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[357, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[437, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[462, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |