Basic Information

NameDNA polymerase eta (EC 2.7.7.7) (Radiation-sensitive protein 30)
Uniprot IDQ04049
Systematic gene nameYDR419W
Standard gene nameRAD30
Gene namesRAD30 DBH1 YDR419W
Description from SGDYDR419W RAD30 SGDID:S000002827, Chr IV from 1303174-1305072, Genome Release 64-3-1, Verified ORF, "DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have a role in protection against mitochondrial mutagenesis; may be involved in meiosis; mutations in human pol eta are responsible for XPV"
Protein length632
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MSKFTWKELI QLGSPSKAYE SSLACIAHID MNAFFAQVEQ MRCGLSKEDP
VVCVQWNSII AVSYAARKYG ISRMDTIQEA LKKCSNLIPI HTAVFKKGED
FWQYHDGCGS WVQDPAKQIS VEDHKVSLEP YRRESRKALK IFKSACDLVE
RASIDEVFLD LGRICFNMLM FDNEYELTGD LKLKDALSNI REAFIGGNYD
INSHLPLIPE KIKSLKFEGD VFNPEGRDLI TDWDDVILAL GSQVCKGIRD
SIKDILGYTT SCGLSSTKNV CKLASNYKKP DAQTIVKNDC LLDFLDCGKF
EITSFWTLGG VLGKELIDVL DLPHENSIKH IRETWPDNAG QLKEFLDAKV
KQSDYDRSTS NIDPLKTADL AEKLFKLSRG RYGLPLSSRP VVKSMMSNKN
LRGKSCNSIV DCISWLEVFC AELTSRIQDL EQEYNKIVIP RTVSISLKTK
SYEVYRKSGP VAYKGINFQS HELLKVGIKF VTDLDIKGKN KSYYPLTKLS
MTITNFDIID LQKTVVDMFG NQVHTFKSSA GKEDEEKTTS SKADEKTPKL
ECCKYQVTFT DQKALQEHAD YHLALKLSEG LNGAEESSKN LSFGEKRLLF
SRKRPNSQHT ATPQKKQVTS SKNILSFFTR KK

Legend

  • X K-acetylation
  • X Phoshorylation
  • X Ubiquitination

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[7, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[14, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[14, Phos]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[17, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[137, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[272, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[275, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[277, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[279, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[287, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[351, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[373, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[399, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[436, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[491, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[493, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[493, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[494, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[494, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[498, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[525, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[525, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[532, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[537, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[542, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[546, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[547, Phos]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[589, Ubi]Swaney, D.L.,  Beltrao, P.,  Starita, L.,  Guo, A.,  Rush, J.,  Fields, S.,  Krogan, N.J.,  Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications)
[603, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[612, Phos]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)
[615, K-acetyl]Wu, P.S., Enervald, E., Joelsson, A., Palmberg, C., Rutishauser, D., Hällberg, B.M., Ström, L. (2020). Post-translational Regulation of DNA Polymerase eta, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. Genetics 216: 1009-1022. (Publication) (All modifications)