Basic Information

NameCardiolipin synthase (CMP-forming) (CLS) (EC 2.7.8.41)
Uniprot IDQ07560
Systematic gene nameYDL142C
Standard gene nameCRD1
Gene namesCRD1 CLS1 YDL142C
Description from SGDYDL142C CRD1 SGDID:S000002301, Chr IV from 202570-201719, Genome Release 64-3-1, reverse complement, Verified ORF, "Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function and for correct integration of membrane-multispanning proteins into the mitochondrial outer membrane; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis"
Protein length283
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MIQMVPIYSC SALLRRTIPK RPFYHVLSGL TVRFKVNPQL NYNLFRDLTR
REYATNPSKT PHIKSKLLNI PNILTLSRIG CTPFIGLFII TNNLTPALGL
FAFSSITDFM DGYIARKYGL KTIAGTILDP LADKLLMITT TLALSVPSGP
QIIPVSIAAI ILGRDVLLAI SALFIRYSTL KLKYPGRVAW NSYWDIVRYP
SAEVRPSQLS KWNTFFQMVY LGSGVLLLLY EKEEGCEKTE EDFEDRKQDF
QKAFSYLGYV TATTTIMSGV SYALKRNAFK LLK

Legend

  • X Phoshorylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[126, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[126, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)