Basic Information

NameExosome complex exonuclease DIS3 (EC 3.1.13.-) (EC 3.1.26.-) (Chromosome disjunction protein 3) (Ribosomal RNA-processing protein 44)
Uniprot IDQ08162
Systematic gene nameYOL021C
Standard gene nameDIS3
Gene namesDIS3 RRP44 YOL021C O2197
Description from SGDYOL021C DIS3 SGDID:S000005381, Chr XV from 285426-282421, Genome Release 64-3-1, reverse complement, Verified ORF, "Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress"
Protein length1001
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MSVPAIAPRR KRLADGLSVT QKVFVRSRNG GATKIVREHY LRSDIPCLSR
SCTKCPQIVV PDAQNELPKF ILSDSPLELS APIGKHYVVL DTNVVLQAID
LLENPNCFFD VIVPQIVLDE VRNKSYPVYT RLRTLCRDSD DHKRFIVFHN
EFSEHTFVER LPNETINDRN DRAIRKTCQW YSEHLKPYDI NVVLVTNDRL
NREAATKEVE SNIITKSLVQ YIELLPNADD IRDSIPQMDS FDKDLERDTF
SDFTFPEYYS TARVMGGLKN GVLYQGNIQI SEYNFLEGSV SLPRFSKPVL
IVGQKNLNRA FNGDQVIVEL LPQSEWKAPS SIVLDSEHFD VNDNPDIEAG
DDDDNNESSS NTTVISDKQR RLLAKDAMIA QRSKKIQPTA KVVYIQRRSW
RQYVGQLAPS SVDPQSSSTQ NVFVILMDKC LPKVRIRTRR AAELLDKRIV
ISIDSWPTTH KYPLGHFVRD LGTIESAQAE TEALLLEHDV EYRPFSKKVL
ECLPAEGHDW KAPTKLDDPE AVSKDPLLTK RKDLRDKLIC SIDPPGCVDI
DDALHAKKLP NGNWEVGVHI ADVTHFVKPG TALDAEGAAR GTSVYLVDKR
IDMLPMLLGT DLCSLKPYVD RFAFSVIWEL DDSANIVNVN FMKSVIRSRE
AFSYEQAQLR IDDKTQNDEL TMGMRALLKL SVKLKQKRLE AGALNLASPE
VKVHMDSETS DPNEVEIKKL LATNSLVEEF MLLANISVAR KIYDAFPQTA
MLRRHAAPPS TNFEILNEML NTRKNMSISL ESSKALADSL DRCVDPEDPY
FNTLVRIMST RCMMAAQYFY SGAYSYPDFR HYGLAVDIYT HFTSPIRRYC
DVVAHRQLAG AIGYEPLSLT HRDKNKMDMI CRNINRKHRN AQFAGRASIE
YYVGQVMRNN ESTETGYVIK VFNNGIVVLV PKFGVEGLIR LDNLTEDPNS
AAFDEVEYKL TFVPTNSDKP RDVYVFDKVE VQVRSVMDPI TSKRKAELLL
K

Legend

  • X Phoshorylation
  • X K-acetylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[2, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[49, Phos]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)
[53, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[75, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[207, K-acetyl]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)
[240, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[243, K-acetyl]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)
[296, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[297, K-acetyl]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)
[336, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[447, K-acetyl]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)
[664, K-acetyl]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)
[698, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[698, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[698, Phos]Zhou, X., Li, W., Liu, Y., Amon, A. (2021. Cross-compartment signal propagation in the mitotic exit network. Elife 10:e63645. (Publication) (All modifications)
[698, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[702, K-acetyl]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)
[741, K-acetyl]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)
[774, K-acetyl]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)
[959, K-acetyl]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)
[995, K-acetyl]Šoštarić, N., O'Reilly, F.J., Giansanti, P., Heck, A.J.R., Gavin, A.C., van Noort, V. (2018). Effects of acetylation and phosphorylation on subunit interactions in three large eukaryotic complexes. Mol Cell Proteomics 17: 2387-2401. (Publication) (All modifications)