Basic Information
| Name | tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase) |
| Uniprot ID | Q08282 |
| Systematic gene name | YOL141W |
| Standard gene name | PPM2 |
| Gene names | PPM2 TYW4 YOL141W |
| Description from SGD | YOL141W PPM2 SGDID:S000005501, Chr XV from 56452-58539, Genome Release 64-3-1, Verified ORF, "AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p" |
| Protein length | 695 |
| Download | sequence (fasta, from Uniprot), modifications (csv format) |
| Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MKNLTTIKQT NKNVKQERRK KYADLAIQGT NNSSIASKRS VELLYLPKLS
SANNFQMDKN NKLLEYFKFF VPKKIKRSPC INRGYWLRLF AIRSRLNSII
EQTPQDKKIV VVNLGCGYDP LPFQLLDTNN IQSQQYHDRV SFIDIDYSDL
LKIKIELIKT IPELSKIIGL SEDKDYVDDS NVDFLTTPKY LARPCDLNDS
KMFSTLLNEC QLYDPNVVKV FVAEVSLAYM KPERSDSIIE ATSKMENSHF
IILEQLIPKG PFEPFSKQML AHFKRNDSPL QSVLKYNTIE SQVQRFNKLG
FAYVNVGDMF QLWESADEAT KKELLKVEPF DELEEFHLFC HHYVLCHATN
YKEFAFTQGF LFDRSISEIN LTVDEDYQLL ECECPINRKF GDVDVAGNDV
FYMGGSNPYR VNEILQLSIH YDKIDMKNIE VSSSEVPVAR MCHTFTTISR
NNQLLLIGGR KAPHQGLSDN WIFDMKTREW SMIKSLSHTR FRHSACSLPD
GNVLILGGVT EGPAMLLYNV TEEIFKDVTP KDEFFQNSLV SAGLEFDPVS
KQGIILGGGF MDQTTVSDKA IIFKYDAENA TEPITVIKKL QHPLFQRYGS
QIKYITPRKL LIVGGTSPSG LFDRTNSIIS LDPLSETLTS IPISRRIWED
HSLMLAGFSL VSTSMGTIHI IGGGATCYGF GSVTNVGLKL IAIAK
SANNFQMDKN NKLLEYFKFF VPKKIKRSPC INRGYWLRLF AIRSRLNSII
EQTPQDKKIV VVNLGCGYDP LPFQLLDTNN IQSQQYHDRV SFIDIDYSDL
LKIKIELIKT IPELSKIIGL SEDKDYVDDS NVDFLTTPKY LARPCDLNDS
KMFSTLLNEC QLYDPNVVKV FVAEVSLAYM KPERSDSIIE ATSKMENSHF
IILEQLIPKG PFEPFSKQML AHFKRNDSPL QSVLKYNTIE SQVQRFNKLG
FAYVNVGDMF QLWESADEAT KKELLKVEPF DELEEFHLFC HHYVLCHATN
YKEFAFTQGF LFDRSISEIN LTVDEDYQLL ECECPINRKF GDVDVAGNDV
FYMGGSNPYR VNEILQLSIH YDKIDMKNIE VSSSEVPVAR MCHTFTTISR
NNQLLLIGGR KAPHQGLSDN WIFDMKTREW SMIKSLSHTR FRHSACSLPD
GNVLILGGVT EGPAMLLYNV TEEIFKDVTP KDEFFQNSLV SAGLEFDPVS
KQGIILGGGF MDQTTVSDKA IIFKYDAENA TEPITVIKKL QHPLFQRYGS
QIKYITPRKL LIVGGTSPSG LFDRTNSIIS LDPLSETLTS IPISRRIWED
HSLMLAGFSL VSTSMGTIHI IGGGATCYGF GSVTNVGLKL IAIAK
Legend
- X Phoshorylation
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
| [40, Phos] | Zhou, X., Li, W., Liu, Y., Amon, A. (2021. Cross-compartment signal propagation in the mitotic exit network. Elife 10:e63645. (Publication) (All modifications) |
| [237, Phos] | Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications) |