Basic Information
Name | Mitochondrial carnitine carrier |
Uniprot ID | Q12289 |
Systematic gene name | YOR100C |
Standard gene name | CRC1 |
Gene names | CRC1 YOR100C YOR3193C |
Description from SGD | YOR100C CRC1 SGDID:S000005626, Chr XV from 514278-513295, Genome Release 64-3-1, reverse complement, Verified ORF, "Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant" |
Protein length | 327 |
Download | sequence (fasta, from Uniprot), modifications (csv format) |
Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MSSDTSLSES SLLKEESGSL TKSRPPIKSN PVRENIKSFV AGGVGGVCAV
FTGHPFDLIK VRCQNGQANS TVHAITNIIK EAKTQVKGTL FTNSVKGFYK
GVIPPLLGVT PIFAVSFWGY DVGKKLVTFN NKQGGSNELT MGQMAAAGFI
SAIPTTLVTA PTERVKVVLQ TSSKGSFIQA AKTIVKEGGI ASLFKGSLAT
LARDGPGSAL YFASYEISKN YLNSRQPRQD AGKDEPVNIL NVCLAGGIAG
MSMWLAVFPI DTIKTKLQAS STRQNMLSAT KEIYLQRGGI KGFFPGLGPA
LLRSFPANAA TFLGVEMTHS LFKKYGI
FTGHPFDLIK VRCQNGQANS TVHAITNIIK EAKTQVKGTL FTNSVKGFYK
GVIPPLLGVT PIFAVSFWGY DVGKKLVTFN NKQGGSNELT MGQMAAAGFI
SAIPTTLVTA PTERVKVVLQ TSSKGSFIQA AKTIVKEGGI ASLFKGSLAT
LARDGPGSAL YFASYEISKN YLNSRQPRQD AGKDEPVNIL NVCLAGGIAG
MSMWLAVFPI DTIKTKLQAS STRQNMLSAT KEIYLQRGGI KGFFPGLGPA
LLRSFPANAA TFLGVEMTHS LFKKYGI
Legend
- X K-Succinylation
- X SUMOylation
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
[174, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[281, SUMO] | Paasch, F., den Brave, F., Psakhye, I., Pfander, B., Jentsch, S. (2018). Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins. J Biol Chem 293: 599-609. (Publication) (All modifications) |