Basic Information

NameHydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)
Uniprot IDQ12320
Systematic gene nameYOR040W
Standard gene nameGLO4
Gene namesGLO4 GER1 YOR040W O2758 OR26.33
Description from SGDYOR040W GLO4 SGDID:S000005566, Chr XV from 407064-407921, Genome Release 64-3-1, Verified ORF, "Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication"
Protein length285
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MKFLLQQIRN MHVKPIKMRW LTGGVNYSYL LSTEDRRNSW LIDPAEPLEV
SPKLSAEEKK SIDAIVNTHH HYDHSGGNLA LYSILCQENS GHDIKIIGGS
KSSPGVTEVP DNLQQYHLGN LRVTCIRTPC HTKDSICYYI KDLETGEQCI
FTGDTLFIAG CGRFFEGTGR DMDMALNQIM LRAVGETNWN KVKIYPGHEY
TKGNVSFIRA KIYSDIGQNK EFDALEQYCK SNECTTGHFT LRDELGYNPF
MRLDDRAVRL AVGDTAGTYP RSVVMQELRK LKNAM

Legend

  • X Phoshorylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[128, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)