Basic Information

NameDihydrofolate synthetase (DHFS) (EC 6.3.2.12)
Uniprot IDQ12676
Systematic gene nameYMR113W
Standard gene nameFOL3
Gene namesFOL3 YMR113W YM9718.12
Description from SGDYMR113W FOL3 SGDID:S000004719, Chr XIII from 494999-496282, Genome Release 64-3-1, Verified ORF, "Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication"
Protein length427
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MAIELGLSRI TKLLEHLGNP QNSLRVLHIA GTNGKGSVCT YLSSVLQQKS
YQIGKFTTPH LVHVTDSITI NNKPIPLERY QNIRLQLEAL NKSHSLKCTE
FELLTCTAFK YFYDVQCQWC VIEVGLGGRL DATNVIPGAN KACCGITKIS
LDHESFLGNT LSEISKEKAG IITEGVPFTV IDGTNEASVI NVVKERCKAL
GSELSVTDSQ LNGNMIDTNS WGCFDLAKLP LNGEYQIFNL RVAMGMLDYL
QMNELIDITK NEVSTRLAKV DWPGRLYRMD YRFDKVSNRT VPILMDGAHN
GSAAVELVKY LRKEYGNQPL TFVMAVTHGK NLEPLLQPLL RPIDQVILTR
FNNVEGMPWI HATDPEEIKD FILTQGYTKE IVIENDLHQV LPSLAHVSDE
QRRPIVVCGS LYLCGELLRI HNSHLRN

Legend

  • X Phoshorylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[155, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[423, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)