Basic Information

NameStructural maintenance of chromosomes protein 6 (DNA repair protein RHC18) (Rad18 homolog)
Uniprot IDQ12749
Systematic gene nameYLR383W
Standard gene nameSMC6
Gene namesSMC6 RHC18 YLR383W L3502.2
Description from SGDYLR383W SMC6 SGDID:S000004375, Chr XII from 885288-888632, Genome Release 64-3-1, Verified ORF, "Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18"
Protein length1114
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MISTTISGKR PIEQVDDELL SLTAQQENEE QQQQRKRRRH QFAPMTQFNS
NTLDEDSGFR SSSDVATADQ DNFLEESPSG YIKKVILRNF MCHEHFELEL
GSRLNFIVGN NGSGKSAILT AITIGLGAKA SETNRGSSLK DLIREGCYSA
KIILHLDNSK YGAYQQGIFG NEIIVERIIK RDGPASFSLR SENGKEISNK
KKDIQTVVDY FSVPVSNPMC FLSQDAARSF LTASTSQDKY SHFMKGTLLQ
EITENLLYAS AIHDSAQENM ALHLENLKSL KAEYEDAKKL LRELNQTSDL
NERKMLLQAK SLWIDVAHNT DACKNLENEI SGIQQKVDEV TEKIRNRQEK
IERYTSDGTT IEAQIDAKVI YVNEKDSEHQ NARELLRDVK SRFEKEKSNQ
AEAQSNIDQG RKKVDALNKT IAHLEEELTK EMGGDKDQMR QELEQLEKAN
EKLREVNNSL VVSLQDVKNE ERDIQHERES ELRTISRSIQ NKKVELQNIA
KGNDTFLMNF DRNMDRLLRT IEQRKNEFET PAIGPLGSLV TIRKGFEKWT
RSIQRAISSS LNAFVVSNPK DNRLFRDIMR SCGIRSNIPI VTYCLSQFDY
SKGRAHGNYP TIVDALEFSK PEIECLFVDL SRIERIVLIE DKNEARNFLQ
RNPVNVNMAL SLRDRRSGFQ LSGGYRLDTV TYQDKIRLKV NSSSDNGTQY
LKDLIEQETK ELQNIRDRYE EKLSEVRSRL KEIDGRLKST KNEMRKTNFR
MTELKMNVGK VVDTGILNSK INERKNQEQA IASYEAAKEE LGLKIEQIAQ
EAQPIKEQYD STKLALVEAQ DELQQLKEDI NSRQSKIQKY KDDTIYYEDK
KKVYLENIKK IEVNVAALKE GIQRQIQNAC AFCSKERIEN VDLPDTQEEI
KRELDKVSRM IQKAEKSLGL SQEEVIALFE KCRNKYKEGQ KKYMEIDEAL
NRLHNSLKAR DQNYKNAEKG TCFDADMDFR ASLKVRKFSG NLSFIKDTKS
LEIYILTTND EKARNVDTLS GGEKSFSQMA LLLATWKPMR SRIIALDEFD
VFMDQVNRKI GTTLIVKKLK DIARTQTIII TPQDIGKIAD IDSSGVSIHR
MRDPERQNNS NFYN

Legend

  • X Phoshorylation
  • X SUMOylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[61, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[62, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[63, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[63, Phos]Zhou, X., Li, W., Liu, Y., Amon, A. (2021. Cross-compartment signal propagation in the mitotic exit network. Elife 10:e63645. (Publication) (All modifications)
[131, Phos]Jones, M.H., Keck, J.M., Wong, C.C., Xu, T., Yates, J.R., Winey, M. (2011). Cell cycle phosphorylation of mitotic exit network (MEN) proteins. Cell Cycle 10: 3435-3440. (Publication) (All modifications)
[343, SUMO]Bhagwat, N.R., Owens, S.N., Ito, M., Boinapalli, J.V,, Poa, P., Ditzel, A., Kopparapu, S., Mahalawat, M., Davies, O.R., Collins, S.R., Johnson, J.R., Krogan, N.J., Hunter, N. (2021). SUMO is a pervasive regulator of meiosis. Elife 10:e57720. (Publication) (All modifications)
[343, SUMO]Yu, Y., Li, S., Ser, Z., Sanyal, T., Choi, K., Wan, B., Kuang, H., Sali, A., Kentsis, A., Patel, D.J., Zhao, X. (2021). Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A 118: e2026844118. (Publication) (All modifications)
[350, SUMO]Bhagwat, N.R., Owens, S.N., Ito, M., Boinapalli, J.V,, Poa, P., Ditzel, A., Kopparapu, S., Mahalawat, M., Davies, O.R., Collins, S.R., Johnson, J.R., Krogan, N.J., Hunter, N. (2021). SUMO is a pervasive regulator of meiosis. Elife 10:e57720. (Publication) (All modifications)
[350, SUMO]Yu, Y., Li, S., Ser, Z., Sanyal, T., Choi, K., Wan, B., Kuang, H., Sali, A., Kentsis, A., Patel, D.J., Zhao, X. (2021). Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A 118: e2026844118. (Publication) (All modifications)
[885, SUMO]Bhagwat, N.R., Owens, S.N., Ito, M., Boinapalli, J.V,, Poa, P., Ditzel, A., Kopparapu, S., Mahalawat, M., Davies, O.R., Collins, S.R., Johnson, J.R., Krogan, N.J., Hunter, N. (2021). SUMO is a pervasive regulator of meiosis. Elife 10:e57720. (Publication) (All modifications)
[989, Phos]Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)