Basic Information

NameCullin-associated NEDD8-dissociated protein 1 homolog (CAND1 homolog) (Longevity-assurance protein 2)
Uniprot IDQ92325
Systematic gene nameYOL025W
Standard gene nameLAG2
Gene namesLAG2 YOL025W
Description from SGDYOL025W LAG2 SGDID:S000005385, Chr XV from 274957-276939, Genome Release 64-3-1, Verified ORF, "Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1"
Protein length660
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MSLHISKLIE QYRSTKDNDL KYMLLRQNFK INDIEDELAP LVNELLLPVL
VEEQDMEILN LVSFQVLPDL VLSMISDPAA AQLGWVISLI CDPLLNQSMI
HANRSFVLIE TLRNVLQKIE NSPHLDYHQP VNSSLEFISK FIVEMKRHMC
DVDAAQLSHS LSESNMLIYI ESLNLLLKFS FFSDAASPSV MVTLPFDILN
DVFTIAQDYS ATNTNESIDR ITEKLLLTST QLTHPVDLEN LCPKMKYNTL
AAVSRIWYKF GPIVDKLFTN RLLPVLFPPQ MGEECNVEDV LEIVHNFHPY
FSIRRLKDNR PLLSDSTISQ LREGLFGMLS ILNDSLTRTQ NENDHGSDNL
IDSDDGFGSD NDPEQQAYLD ELVSEGYDEN MYDGDTDDED ADDINVEKND
EATKDITETN KILLIFSELH YPQEERFSEL LVELQTKIAI NTSLIDKILS
KETTELPTHN GEIADLNEIL NEVKGNKPIR KNVIFCTLAH TLSLQSGSEL
SVLQLSIEVI DHLLVKNHSN NITRGEQFQL IKLILPHLKT NKSFIDTLKA
GNFTQKIDEG VTLRTMILSL LLQLFPLDYS MLGEILPTIA RYSVRDKDLG
VRDLSFQLLD QILRTYYNYL IGIDWEWYKD DFYQVLQETC IKKDINTNLL
LQFPPYLPHD

Legend

  • X Neddylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[16, Nedd]Siergiejuk, E., Scott, D.C., Schulman, B.A., Hofmann, K., Kurz, T., Peter, M. (2009). Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28: 3845-3856. (Publication) (All modifications)