Basic Information
Name | Cullin-associated NEDD8-dissociated protein 1 homolog (CAND1 homolog) (Longevity-assurance protein 2) |
Uniprot ID | Q92325 |
Systematic gene name | YOL025W |
Standard gene name | LAG2 |
Gene names | LAG2 YOL025W |
Description from SGD | YOL025W LAG2 SGDID:S000005385, Chr XV from 274957-276939, Genome Release 64-3-1, Verified ORF, "Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1" |
Protein length | 660 |
Download | sequence (fasta, from Uniprot), modifications (csv format) |
Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MSLHISKLIE QYRSTKDNDL KYMLLRQNFK INDIEDELAP LVNELLLPVL
VEEQDMEILN LVSFQVLPDL VLSMISDPAA AQLGWVISLI CDPLLNQSMI
HANRSFVLIE TLRNVLQKIE NSPHLDYHQP VNSSLEFISK FIVEMKRHMC
DVDAAQLSHS LSESNMLIYI ESLNLLLKFS FFSDAASPSV MVTLPFDILN
DVFTIAQDYS ATNTNESIDR ITEKLLLTST QLTHPVDLEN LCPKMKYNTL
AAVSRIWYKF GPIVDKLFTN RLLPVLFPPQ MGEECNVEDV LEIVHNFHPY
FSIRRLKDNR PLLSDSTISQ LREGLFGMLS ILNDSLTRTQ NENDHGSDNL
IDSDDGFGSD NDPEQQAYLD ELVSEGYDEN MYDGDTDDED ADDINVEKND
EATKDITETN KILLIFSELH YPQEERFSEL LVELQTKIAI NTSLIDKILS
KETTELPTHN GEIADLNEIL NEVKGNKPIR KNVIFCTLAH TLSLQSGSEL
SVLQLSIEVI DHLLVKNHSN NITRGEQFQL IKLILPHLKT NKSFIDTLKA
GNFTQKIDEG VTLRTMILSL LLQLFPLDYS MLGEILPTIA RYSVRDKDLG
VRDLSFQLLD QILRTYYNYL IGIDWEWYKD DFYQVLQETC IKKDINTNLL
LQFPPYLPHD
VEEQDMEILN LVSFQVLPDL VLSMISDPAA AQLGWVISLI CDPLLNQSMI
HANRSFVLIE TLRNVLQKIE NSPHLDYHQP VNSSLEFISK FIVEMKRHMC
DVDAAQLSHS LSESNMLIYI ESLNLLLKFS FFSDAASPSV MVTLPFDILN
DVFTIAQDYS ATNTNESIDR ITEKLLLTST QLTHPVDLEN LCPKMKYNTL
AAVSRIWYKF GPIVDKLFTN RLLPVLFPPQ MGEECNVEDV LEIVHNFHPY
FSIRRLKDNR PLLSDSTISQ LREGLFGMLS ILNDSLTRTQ NENDHGSDNL
IDSDDGFGSD NDPEQQAYLD ELVSEGYDEN MYDGDTDDED ADDINVEKND
EATKDITETN KILLIFSELH YPQEERFSEL LVELQTKIAI NTSLIDKILS
KETTELPTHN GEIADLNEIL NEVKGNKPIR KNVIFCTLAH TLSLQSGSEL
SVLQLSIEVI DHLLVKNHSN NITRGEQFQL IKLILPHLKT NKSFIDTLKA
GNFTQKIDEG VTLRTMILSL LLQLFPLDYS MLGEILPTIA RYSVRDKDLG
VRDLSFQLLD QILRTYYNYL IGIDWEWYKD DFYQVLQETC IKKDINTNLL
LQFPPYLPHD
Legend
- X Neddylation
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
Use imported representation
Loading structure from server... It may take a while.
If you believe something went wrong, please make sure PDB ID is correct.
Please also make sure that WebGL is enabled in your browser.
- Internet Explorer: sorry. IE doesn't support WebGL.
- Firefox (version 4 or later): try force enable WebGL.
- Chrome: try force enable WebGL.
- Safari: enable WebGL.
References
[16, Nedd] | Siergiejuk, E., Scott, D.C., Schulman, B.A., Hofmann, K., Kurz, T., Peter, M. (2009). Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28: 3845-3856. (Publication) (All modifications) |