Basic Information
Name | Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Enoyl reductase TSC13) (Temperature-sensitive CSG2 suppressor protein 13) (Trans-2-enoyl-CoA reductase) |
Uniprot ID | Q99190 |
Systematic gene name | YDL015C |
Standard gene name | TSC13 |
Gene names | TSC13 YDL015C D2865 |
Description from SGD | YDL015C TSC13 SGDID:S000002173, Chr IV from 426934-426002, Genome Release 64-3-1, reverse complement, Verified ORF, "Enoyl reductase; catalyzes last step in each cycle of very long chain fatty acid elongation; localizes to ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Elo2p and Elo3p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress; human homolog TECR implicated in nonsyndromic mental retardation, can complement yeast mutant" |
Protein length | 310 |
Download | sequence (fasta, from Uniprot), modifications (csv format) |
Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MPITIKSRSK GLRDTEIDLS KKPTLDDVLK KISANNHNIS KYRIRLTYKK
ESKQVPVISE SFFQEEADDS MEFFIKDLGP QISWRLVFFC EYLGPVLVHS
LFYYLSTIPT VVDRWHSASS DYNPFLNRVA YFLILGHYGK RLFETLFVHQ
FSLATMPIFN LFKNCFHYWV LSGLISFGYF GYGFPFGNAK LFKYYSYLKL
DDLSTLIGLF VLSELWNFYC HIKLRLWGDY QKKHGNAKIR VPLNQGIFNL
FVAPNYTFEV WSWIWFTFVF KFNLFAVLFL TVSTAQMYAW AQKKNKKYHT
RRAFLIPFVF
ESKQVPVISE SFFQEEADDS MEFFIKDLGP QISWRLVFFC EYLGPVLVHS
LFYYLSTIPT VVDRWHSASS DYNPFLNRVA YFLILGHYGK RLFETLFVHQ
FSLATMPIFN LFKNCFHYWV LSGLISFGYF GYGFPFGNAK LFKYYSYLKL
DDLSTLIGLF VLSELWNFYC HIKLRLWGDY QKKHGNAKIR VPLNQGIFNL
FVAPNYTFEV WSWIWFTFVF KFNLFAVLFL TVSTAQMYAW AQKKNKKYHT
RRAFLIPFVF
Legend
- X Ubiquitination
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
[21, Ubi] | Swaney, D.L., Beltrao, P., Starita, L., Guo, A., Rush, J., Fields, S., Krogan, N.J., Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications) |