Computational Biology
@ Comenius University in Bratislava

Panda Genome Sequencing and Analysis Consortium. The sequence and de novo assembly of the giant panda genome. Nature, 463(7279):269-392. 2010.

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Download from publisher: http://dx.doi.org/10.1038/nature08696

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Abstract:

Using next-generation sequencing technology alone, we have successfully
generated and assembled a draft sequence of the giant panda genome. The
assembled contigs (2.25 gigabases (Gb)) cover approximately 94% of the
whole genome, and the remaining gaps (0.05 Gb) seem to contain
carnivore-specific repeats and tandem repeats. Comparisons with the dog
and human showed that the panda genome has a lower divergence rate. The
assessment of panda genes potentially underlying some of its unique traits
indicated that its bamboo diet might be more dependent on its gut
microbiome than its own genetic composition. We also identified more than
2.7 million heterozygous single nucleotide polymorphisms in the diploid
genome. Our data and analyses provide a foundation for promoting mammalian
genetic research, and demonstrate the feasibility for using
next-generation sequencing technologies for accurate, cost-effective and
rapid de novo assembly of large eukaryotic genomes.