Computational Biology
@ Comenius University in Bratislava

Michal Nanasi, Tomas Vinar, Brona Brejova. The Highest Expected Reward Decoding for HMMs with Application to Recombination Detection. Technical Report arXiv:1001.4499, arxiv.org, January 2010.

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Download from publisher: http://arxiv.org/pdf/1001.4499

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Abstract:

Hidden Markov models are traditionally decoded by the Viterbi algorithm 
which finds the highest probability state path in the model. In recent 
years, several limitations of the Viterbi decoding have been demonstrated, 
and new algorithms have been developed to address them (Kall et al., 2005; 
Brejova et al., 2007; Gross et al., 2007; Brown and Truszkowski, 2010).

In this paper, we propose a new efficient highest expected reward decoding 
algorithm (HERD) that allows for uncertainty in boundaries of individual 
sequence features. We demonstrate usefulness of our approach on jumping 
HMMs for recombination detection in viral genomes. 

Keywords: hidden Markov models, decoding algorithms, recombination detection, jumping HMMs